四川轮环藤根中两种新双苄基异喹啉生物碱的分离鉴定  

TWO NOVEL BISBENZYLISOQUINOLINE ALKALOIDS FROM CYCLEA SUTCHUENENSIS GAGNEP

作　　者：赖盛[1] 赵同芳[1] 王宪楷[1] 志津里芳一 山村庄亮 

机构地区：[1]华西医科大学药学院,成都610041 [2]庆应义塾大学理工学部

出　　处：《药学学报》1993年第8期599-603,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金

摘　　要：从中国特有植物四川轮环藤(Cyclea sutchuenensis Gagnep.)根中除分得已知的轮环藤碱(Ⅰ)和异粒枝碱(Ⅱ)外,还分离得到两种新双苄基异喹啉生物碱,分别命名为异轮环藤碱(Ⅲ)和四川轮环藤辛碱(Ⅳ)。经物理常数和波谱数据分析鉴定,证明Ⅲ为轮环藤碱的差向异构体,Ⅳ系一种新型的8-12′,12-7′首尾双氧桥双苄基异喹啉生物碱。In addition to the known cycleanine (Ⅰ) and d-isochondodendrine (Ⅱ), two novel bisbenzylisoquinoline alkaloids named isocycleanine (Ⅲ) and sutchuenensine (Ⅳ) have been isolated from the roots of Cyckea sutchuenensis Gagnep grown wild in Sichuan province, China. Ⅲ was established as the epimer of Ⅰ and Ⅳ, as a new type of head-to-tail bisbenzylisoquinoline alkaloid with two diarylether bridges in between C-8 to C-12′ and C-12 to C-7′ on the basis of physical constants and spectral data (UV, IR, ELMS, ~1HNMR and NOEDS).

关 键 词：四川轻环藤 生物碱 辛碱 

分 类 号：R931.6[医药卫生—生药学]