HBV感染与原发性肝癌关系的探讨  

THE RELATIONSHIP BETWEEN HEPATITIS B VIRUS INFECTION AND PRIMARY HEPATOCELLULAR CARCINOMA

作　　者：李长林[1] 李秋梅[2] 姜宝法[1] 冯月秋[1] 李笠[1] 

机构地区：[1]山东医科大学流行病学教研室 [2]山东医科大学传染病学教研室

出　　处：《山东医科大学学报》1989年第3期45-47,共3页Acta Academiae Medicinae Shandong

摘　　要：采用配比的方法,以原发性肝癌、肝硬化、慢性乙型肝炎和非肝病病人为研究对象,检测其HBV感染6项血清学标志。结果表明,原发性肝癌、肝硬化、慢性肝炎的HBV感染总阳性率分别为98.21%,93.75%和96.43%;与对照组有显著差异;3组的感染标志组合较一致,HBsAg和抗-HBc双阳性为主;HBeAg在肝硬化和慢性肝炎中明显高于肝癌组;抗-HBe和抗-HBcIgM3组间无显著差别。提示HBV感染的慢性化与原发性肝癌病因有密切联系。In an attempt to clarify the relationship between HBV in- fection and hepatocellular carcinoma,we have studied the HBV infection serum marks in 448 patients suffering from hepatocellular carcinoma (PHC),chronic hepatitis B(CHB),liver cirrhosis(LC)and non-liver di- seases(NLD).The incidence of HBV infection serum marks were res- pectively 98.21% in PHC,96.43% in CHB and 93.75% in LC,signifi- cantly higher than that in controls,The major combination of serum marks was HBsAg and anti-HBC among liver disease patients,The incidence for anti-HBe and anti-HBcIgM were no significant difference among the three liver disease groups,but HBeAg was significantly higher in CHB and in LC.The result indicated HBV infection was closely associ- ated with PHC.

关 键 词：肝肿瘤 肝硬变 原发性 乙型肝炎 

分 类 号：R512.62[医药卫生—内科学]