ι─荷牡丹碱对豚鼠结肠带收缩作用的影响  

Effects ofι─Dicentrine on Contractility of Isolated Guinea Pig Taenia Coli

作　　者：李惠兰[1] 王方材[1] 侯云成[1] 梁红媛[1] 

机构地区：[1]昆明医学院药理教研室,云南中医学院

出　　处：《昆明医学院学报》1994年第2期36-39,共4页Journal of Kunming Medical College

摘　　要：用离体实验法研究ι─荷包牡丹碱对豚鼠结肠带收缩的影响，结果发现：ι─荷包牡丹碱明显拮抗组织胺及ｃａ２＋引起的收缩，呈现非竞争性拮抗方式，ｐＤ＇２分别为４．９２及５．４３．在无ｃａ２＋液中，ι─荷包牡丹碱与罂粟碱相似，能抑制组织胺诱发的结肠带收缩．提示两药对结肠带依赖细胞内Ｃａ２＋所致的收缩均有明显的抑制，当恢复细胞外Ｃａ２＋浓度后，两药对依赖细胞外Ｃａ２＋经ＲＯＣ内流所致的收缩无影响．The contractions induced by histamine or Ca2+ after high K+ depolarization in isolatedguinea─pig taenia coli were markedly inhibited by ι─dicentrine or papaverine. It causedrightward displacement of the dose─response curve for histamine or CaCl2 ι─dicentrinesignificantly depressed maximal response,showing a non─competitive antagonism. The PD2value of ι─dicentrine was 4.92 and 5.3 respectively. in Ca2+ free solution,ι─Dicentrine issimilar to papavering inhibited histamine─induced contraction of guinea─pig taenia coli,which is dependent on Ca2+ released from intracellular store. After Ca2+ concentration inbath solution was restored,ι─dicentrine did not influence the contraction of taenia coli de-pending on extracellular Ca2+.

关 键 词：结肠带 荷包牡丹碱 豚鼠 细胞外 药对 细胞内CA^2+ 收缩作用 拮抗 离体实验 组织胺 

分 类 号：R285.5[医药卫生—中药学] Q426[医药卫生—中医学]