氯洁霉素的合成  

Synthesis of Clindamycine

作　　者：李少华 宫京闵 李刚 

出　　处：《江西教育学院学报》1994年第6期23-25,共3页Journal of Jiangxi Institute of Education

摘　　要：以洁霉素为原料．采用Ｒｙｄｏｎ试剂．对其Ｃ─７位的羟基进行氯代，同时构型转变。所得产物为一优良的半合抗，其药效较洁霉素高４─８倍。本文并对其后处理工艺进行了研讨，用乙醚处理粗产品，产物的效价及晶形均较标品为优。Via Subs titution of chlorine to lincomycine molecule's C─7─(R) hydroxyl ,reaction of lincomycine with Rydon reagent givis a compound that has undergone inversion of configuration. The compound is a kind of fine antibiotic, and its curative effect is 4─8 times as efficacious as linconiycine.this article has discussed the aftertreatment process of the synthetic reactions,After the rough product is treated with diethyl ether , both its colour and crystal are,better than standard sample.

关 键 词：氯洁霉素 Rydon试剂 三苯膦 实验步骤 半合成抗生素 

分 类 号：TQ465[化学工程—制药化工]