甘草酸单铵对内毒素诱发支气管高反应性的作用─β－cAMP向下调节影响  

Effect of Ammonium Glycyrrhizanate agsinst endotoxininduced bronchial hyperrractivity-in relation to β-cAMP system

作　　者：陈剑雄[1,2] 曹永舒[1,2] 

机构地区：[1]衡阳医学院药理教研室 [2]河南医科大学药理教研室

出　　处：《中药药理与临床》1994年第1期17-18,共2页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：内毒素１ｍｇ／ｋｇｉｐｄ４豚鼠气道Ｈｉｓ引喘潜伏期明显缩短，Ｈｉｓ反应性增强，其ＰＤ２值增大，β受体功能降低，ＩＳＯ的ＰＤ２值下降，血浆中ｃＡＭＰ水平降低，甘草酸单铵（ＧＬ）５０ｍｇ／ｋｇｉｐ×４ｄ明显抑制ｉｐ内毒素后Ｈｉｓ反应性增高及β受体反应性降低，并显著提高血浆ｃＡＭＰ水平。提示ＧＬ对细菌感染诱发的支气管高反应性有预防作用，其作用机制与ＧＬ对β－ｃＡＭＰ系统向上调节有关。days after endotoxin 1mg/kg intraperitoneal injection,the latent peroids of guinea pig inhaled histamine and PD2value of ISO and cAMP levels of plasma were decrease. meanwhile PD2 value of histamine decreased significantly.Ammonium Glycyrrhizanate50mg/kg ip×4inhibited the effect of endotoxin and incteased cAMP levels of plasma.The results indicated GL could prevent bscterial infection induced bronchial hyperreactivity. The mechanism may be inretation to that GL could be up regulation of β-cAMP system.

关 键 词：内毒素 支气管高反应性 诱发 甘草酸单铵 PD 血浆 AMP 增强 降低 缩短 

分 类 号：R562.25[医药卫生—呼吸系统] R742.5[医药卫生—内科学]