石蓝草煎剂的抗变态反应作用  

The Anti-hypersensitive Action of"Gypsum Fibrosum-Fibrosum-Isatis-Gentiana Scabra Mixture

作　　者：袁盛榕[1] 杨东旭[1] 姚娴[1] 王丽娟[1] 

机构地区：[1]首都医学院药理教研室

出　　处：《中药药理与临床》1994年第1期22-23,4,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：ＧＩＧＭ，６９．０ｇ／（ｋｇ·ｄ）×３和３４．５ｇ／（ｋｇ·ｄ）×１７，ｉｇ给药，可显著抑制小鼠腹腔巨噬细胞的吞噬功能和ＤＮＣＢ所致的小鼠迟发型变态反应；抑制致敏豚鼠离休回肠的Ｓｃｈｕｌｔｚ－Ｄａｌｅ反应；直接对抗组胺、５－ＨＴ引起的正常豚鼠离休回肠的收缩作用，ＩＣ５０分别为４０ｍｇ／ｍｌ和２ｍｇ／ｍｌ；其ＬＤ５０±Ｌ９５为５８０．４±１０７．６ｇ／ｋｇ。Gypsum Fibrosum-Isatis-Gentiana Scabra Mixture' (GIGM) 69.0g/ (kg. d)×3 and 34. 5g./ (kg. d) )×17,is) not only signitficantly dcerased the clearance rats of charcoal particles and inhibited delayed hypersensitive byDNCB in mice in vivo. but also significangtly inhibited contraction of ileum in sensitived auina pig and the contractionof ileum by histamin and 5-HT in norma guina pig in vitro.in dose-related manner.

关 键 词：煎剂 抗变态反应作用 离体回肠 致敏 抗组胺 正常 吞噬功能 直接 抑制 给药 

分 类 号：R285.5[医药卫生—中药学] R289.5[医药卫生—中医学]