Stepwise Method Based on Confidence Bound and Information Incorporation for Identifying the Maximum Tolerable Dose  

作　　者：王雪丽 陶剑 史宁中 

机构地区：[1]Department of Mathematics Daqing Petroleum Institute, Daqing, Heilongjiang,163318 Research Instetute of Mathematics, Jilin University, Changchun,130012 [2]Department of Mathematics Northeast Normal University, Changchun, 130024

出　　处：《Northeastern Mathematical Journal》2005年第1期117-126,共10页东北数学（英文版）

基　　金：The NNSF (10201006, 10001008) of China.

摘　　要：The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine the maximum tolerable dose among given dose levels. On the one hand, in order to avoid severe even fatal toxicity to occur and reduce the experimental subjects, the new method is executed from the lowest dose level, and then goes on in a stepwise fashion. On the other hand, in order to improve the accuracy of the recommendation, the final recommendation of the maximum tolerable dose is accomplished through the information incorporation of an additional experimental cohort at the same dose level. Furthermore, empirical simulation results show that the new method has some real advantages in comparison with the modified continual reassessment method.The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine the maximum tolerable dose among given dose levels. On the one hand, in order to avoid severe even fatal toxicity to occur and reduce the experimental subjects, the new method is executed from the lowest dose level, and then goes on in a stepwise fashion. On the other hand, in order to improve the accuracy of the recommendation, the final recommendation of the maximum tolerable dose is accomplished through the information incorporation of an additional experimental cohort at the same dose level. Furthermore, empirical simulation results show that the new method has some real advantages in comparison with the modified continual reassessment method.

关 键 词：confidence bound continual reassessment method information incorporation maximum tolerable dose phase I clinical trials stepwise method 

分 类 号：R96[医药卫生—药理学]