苯那普利对小儿原发性肾病综合征脂质代谢及微循环的影响  

Effect of benazepril on serum lipid and microcirculation in children with nephrotic syndrome

作　　者：刘娅[1] 蒋红侠 高秀梅[1] 

机构地区：[1]徐州市中心医院儿科,江苏徐州221009

出　　处：《现代医学》2004年第6期379-381,共3页Modern Medical Journal

摘　　要：目的　探讨血管紧张素转换酶抑制剂对肾病综合征患儿血脂、微循环及疗效的影响。方法　将 3 8例服用泼尼松的肾病综合征患儿分为治疗组 (n =18)及对照组 (n =2 0 ) ,治疗组在常规激素治疗基础上加服苯那普利2 .5～ 5mg·d-1,检测两组治疗前后血脂、肾功能及微循环等指标。结果　两组治疗后 2 4h尿蛋白定量均显著低于治疗前 (P <0 .0 5 )。对照组治疗前后血脂无显著变化 (P >0 .0 5 ) ,微循环中血流速度等无明显改善 ;而治疗组治疗前后各项生化指标、血流速度及红细胞聚集现象均明显改善 (P <0 .0 5 )。结论　苯那普利可降低肾病综合征血脂水平 ,改善其外周微循环 ,提高疗效。Objective To investigate the effect of angiotensin converting enzyme inhibitor (ACEI), benazepril on blood-lipid and microcirculation in children with nephrotic syndrome(NS). Methods Thirty-eight cases of children treated with NS therapeutics were divided into control group and treatment group. Treatment group was given benazepril with 2.5～5-mg·d -1. The blood-lipid, serum creatine and 24 hours urine protein were detected before and after treatment. Results After treatment the levels of 24 hours urine protein decreased significantly both treatmented group and control group ( P<0.05). The level of serum lipids and microcirculation were not significantly difference in control group before and after treatment. The level of blood-lipid decreased significantly (P<0.05) and microcirculation was improved in treatment group.Conclusions Benazepril can decrease the level of blood-lipid and improve microcirculation for the children with NS.

关 键 词：微循环 苯那普利 治疗前后 治疗组 血脂 肾病综合征 对照组 结论 现象 目的 

分 类 号：R692[医药卫生—泌尿科学] R541.4[医药卫生—外科学]