锰(Ⅳ)-安乃近-甲醛化学发光体系的研究  

Chemiluinescence determination of metamizde sodium with soluble Mn (Ⅳ)-formaldehyde system

作　　者：张红鸽[1] 祝兴华[2] 何云华[2] 

机构地区：[1]宝鸡文理学院化学化工系,宝鸡721007 [2]陕西师范大学化学与材料科学学院,西安710062

出　　处：《分析试验室》2005年第1期5-7,共3页Chinese Journal of Analysis Laboratory

摘　　要：实验发现锰(Ⅳ)氧化安乃近可以产生弱的化学发光,甲醛对这一化学发光反应有较强的增敏作用。据此建立了测定安乃近的流动注射化学发光分析法。在最优化的条件下,测定安乃近的线性范围为6 0×10-7～1 0×10-5mol/L,检出限为2×10-7mol/L安乃近。对1.0×10-6mol/L安乃近进行11次测定,相对标准偏差为3.4%。该方法已应用于针剂中安乃近的测定,其结果与药典方法测得值一致。A novel chemiluminescence method for the determination of metamizde sodium with flow injection technique, based on formaldehyde enhancing the chemiluminescence from the oxidation of metamizde sodium by soluble Mn (Ⅳ), has been developed. Under optimum conditions, the linear dynamic range for the determination of metamizde sodium was 6.0×10^(-7) to 1.0×10^(-5) mol/L, and the detection limit was 2×10^(-7) mol/L. The relative standard deviation for the determination of 1.0×10^(-6)mol/L metamizde sodium (n=11) was 3.4%. The method has been applied to the determination of metamizde sodium in injections, and the results were in good agreement with those obtained by pharmacopoeia method.

关 键 词：化学发光 锰(Ⅳ) 安乃近 甲醛 流动注射 

分 类 号：O657.32[理学—分析化学]