肠安康胶囊对小鼠炎症和免疫功能的影响  

Effect of Changankang Capsule on inflammation and immune function in mice

作　　者：王献坤[1] 郑晓鹤[1] 邢建峰[1] 侯家玉[1] 

机构地区：[1]北京中医药大学中药学院中药药理系,北京100102

出　　处：《中成药》2004年第12期1043-1045,共3页Chinese Traditional Patent Medicine

基　　金：国家中医药管理局新药开发专项(DIX034A)

摘　　要：目的研究肠安康胶囊(黄芪、黄连、金银花等)对小鼠急性炎症和免疫功能的影响。方法观察肠安康对二甲苯致小鼠耳肿胀和醋酸致毛细血管通透性增高急性炎症的影响;以二硝基氟苯诱发小鼠迟发型超敏反应(DTH),观察耳肿胀度、淋巴细胞增殖能力,同时检测血清中肿瘤坏死因子α(TNFα)、白细胞介素1β(IL1β)的变化。结果肠安康胶囊能明显抑制小鼠急性炎症,抑制DTH小鼠耳肿胀,抑制T、B淋巴细胞增殖,降低血清中TNFα的含量,但对IL1β的含量无明显影响。结论肠安康胶囊有明显的抗炎和对DTH的抑制作用,降低TNFα的含量可能是其作用途径之一。AIM: To investigate the effect of Changankang Capsule (Radix Astragali, Rhizoma Coptidis, Flos Lonicerae, etc.) on acute inflammation and immune function in mice. METHODS:Swelling ears induced dimethylbenzene and capillary vessel increase permeability induced by acetic acid, 2,4 diniitrofluorobenzene (DNFB) induced delayed type hypersensitivity (DTH) was adoptedas mouse model. extent of swelling ears, lymphocyte proliferation and the Tumor necrosis factor α and interleukin 1 β in serum were observed. RESULTS:Changankang had significantly anti inflammation in mouse's acute inflammatory model and could inhibit swelling ears and lymphocyte proliferation, decreased the level of TNF α, but made little iufluence on IL 1β change. CONCLUSION:Changankang Capsule has the effect on anti inflammation and inhibitory effect on the DTH. Its action mechanism may be related to the inhibition of the production of TNF α.

关 键 词：肠安康胶囊 急性炎症 迟发型超敏反应 细胞因子 

分 类 号：R285.5[医药卫生—中药学]