HBV感染者所产新生儿分型免疫研究  

The Study of New Born of Suffering HBV is Divided into Different Types to be Immunity

作　　者：张平[1] 朱理珉[1] 张玉荣[1] 李伟[1] 陈静[1] 郝金玉[1] 国心[1] 

机构地区：[1]天津市传染病医院,300192

出　　处：《天津医药》2005年第2期90-92,共3页Tianjin Medical Journal

基　　金：天津市卫生局级科研课题00Ky02

摘　　要：目的:探讨乙型肝炎(乙肝)病毒(HBV)感染孕妇分娩的新生儿在宫内从母体获得的HBV标志物和HBVDNA程度分型临床意义,旨在有效地阻断乙肝病毒的母婴传播。方法:检测HBV感染孕妇分娩的831例新生儿产后2h内静脉血中乙肝病毒标志物,根据获得的不同HBV标志物和HBVDNA状态分为5型,各型进行不同剂量的乙肝免疫球蛋白和乙肝疫苗免疫,于产后7～8个月龄时复查。分型免疫组665例,对照组166例。结果:分型免疫组7～8个月复查新生儿HBV感染情况与对照组差别有统计学意义(P<0.05)。结论:分型免疫效果优于一般免疫效果,可进一步降低HBV感染者分娩的新生儿的感染率。Objective: In order to cut off validly HBV from mother to new born, it is divided into different types according to the embryo acquired HBV-markers and HBV DNA degrees. Methods: HBV-markers and HBV DNA were tested for 831 new born within 2 hours from 825 HBsAg positive mothers and divided into 5 types in order to run several immunity methods of HBIG(hepatitis B immunity globulin ) and hepatitis B vaccine. Six hundred and sixty five new born as a treatment group and control group of 166 were retested in 7～8 month old. Results: The immunity effect were significant different between the treatment and control groups(P < 0.05). Conclusion: The effect of running immunity according different types is better than the traditional immunity. It is an important step to prevent HBV from morthers to their infants effectively.

关 键 词：分型 HBV感染 新生儿 对照组 免疫组 HBV标志物 分娩 查新 结论 一般 

分 类 号：R512.62[医药卫生—内科学] R722[医药卫生—临床医学]