老年冠心病患者肿瘤坏死因子-β基因多态性的研究  

Study of tumor necrosis factor-β gene polymorphism in patients with coronary heart disease

作　　者：陈志群[1] 郑宗富[1] 马建芳[1] 邱凤英[1] 施水兰[1] 陈宏[1] 林红[1] 王月娥[1] 

机构地区：[1]中国人民解放军第476医院内三科,福建省福州市350002

出　　处：《中国全科医学》2002年第2期111-112,共2页Chinese General Practice

摘　　要：目的　对老年冠心病 (CHD)患者肿瘤坏死因子 - β (TNF - β)基因多态性进行分析 ,探讨其在冠心病发病中的作用。方法　用PCR法测定 4 0例CHD患者及 3 0例对照者的TNF - β等位基因频率并进行比较。 结果　TNF - β等位基因频率分布 ,两组之间比较差异无显著性意义 ( P >0 0 5 )。结论　TNF -Objective To analyse the tumor necrosis factor-β(TNF-β) gene polymorphism in patients with coronary heart disease (CHD) and its clinical significance.Methods The TNF gene-β polymorphism in 40 patents with CHD were measured by Polymerase chain reaction(PCR) and 30 normal subjects as the control.Results The frequency of TNF-β gene polymorphism distributed in CHD,as well as that in normal group.Conclusion TNF-β gene polymorphism may be not a correlative gene of essential CHD.

关 键 词：TNF 患者 基因多态性 肿瘤坏死因子-Β CHD 老年冠心病 发病 结论 重要作用 显著性 

分 类 号：R541.4[医药卫生—心血管疾病] R259.[医药卫生—内科学]