耐甲氧西林葡萄球菌的耐药性监测及分析  

Drug Resistance Supervision and Analysis of Meticillin-resistantStaphylococcus

作　　者：赵建平[1] 周秀岚[2] 贾少荣[1] 孙丽萍[1] 张秀屏[1] 冯笑梅[1] 

机构地区：[1]内蒙古自治区医院,内蒙古呼和浩特010017 [2]内蒙古医学院附属医院,内蒙古呼和浩特010050

出　　处：《中华医院感染学杂志》2004年第9期1052-1054,共3页Chinese Journal of Nosocomiology

基　　金：内蒙古自治区科学技术攻关资助项目(990 12 2 ;2 0 0 0 0 2 11)

摘　　要：目的　监测葡萄球菌 (包括 MRS和 MSS株 )的耐药性 ,为临床合理选择抗生素提供依据。方法　药敏试验及耐甲氧西林葡萄球菌的检测均采用琼脂扩散法 (K- B法 ) ,操作及结果判断均按 NCCL S标准执行。结果　金黄色葡萄球菌与凝固酶阴性葡萄球菌的分离率分别占 2 7.3%和 72 .7% ;MRSA和 MRSCON株的检出率分别为33.8%和 78.6 % ;MRSA株对喹诺酮类的耐药性 (2 2 %～ 5 5 % )明显低于 MRSCON株 (84 %～ 90 % ) ;除万古霉素、呋喃妥因、阿米卡星和部分青霉素类外 ,MRSA和 MRSCON株的耐药性显著高于 MSSA和 MSSCON株(P<0 .0 5 ) ;未发现 VRS株。结论　由 MRS菌株引起的严重感染首选万古霉素治疗 ,发现 MRS株实验室要根据 NCCL S的有关规定修订药敏报告 ,并且及时切断传播途径 。OBJECTIVE To supervise the drug resistance of Staphylococcus (included MRS and MSS) and give foundation for clinic to choose antibiotic rationally. METHODS The MRSA and the drug sensitivity test in vitro were tested by K-B method, according the NCCLS standard to manipulate and judge the results. RESULTS The detectable rate of TBXS. aureus, coagulase-negative staphylococcus, MRSA and MRSCON was 27.3%, 72.7%, (33.8%,) and 78.6%, respectively. The drug resistance of MRSA to quinolones was lower than MRSCON except vancomycin, nitrofurantoin, amikacin and some penicillins. The drug resistance of MRSA and MRSCON was obviously higher than MSSA and MSSCON (P<0.05), VRS was not detected. CONCLUSIONS Vancomycin should be chosen firstly when the infection is clue to MRS and revise the drug sensitivity report according the relevant stipulation of NCCLS, then cut off the spread way and lower the drug resistance and hospital infection.

关 键 词：甲氧西林 葡萄球菌 耐药性 抗生素 

分 类 号：R378.11[医药卫生—病原生物学]