铁筷子多糖抑制鼠S180生长的形态学观察  

Antineoplastic Effect in morphology of Helleborus thibetanus Franch polysaccharose

作　　者：王振军[1] 刘立伟[1] 苗芳[1] 

机构地区：[1]泰山医学院,山东泰安271000

出　　处：《泰山医学院学报》2004年第5期431-432,共2页Journal of Taishan Medical College

摘　　要：目的　观察铁筷子多糖 (HelleborusthibetanusFranchpolysaccharose,HFPS)对小鼠体内肉瘤S180生长的影响及荷瘤鼠肉瘤、胸腺组织的组织学变化。方法　设立正常对照组、肿瘤模型组、铁筷子多糖处理组和阳性对照组 (复方天仙胶囊处理组 )。用小鼠肉瘤S180细胞株建立动物肿瘤模型 ,灌胃给予荷S180小鼠HFPS后 ,计算抑瘤率及观察荷瘤鼠胸腺组织及肉瘤组织的形态变化。结果　铁筷子多糖有明显抑制S180肉瘤细胞体内生长的作用 ;对照鼠S180肉瘤模型 ,多糖 (HFPS)治疗组荷瘤小鼠胸腺皮质厚度较明显增加 ,胸腺细胞增多 ;小鼠肉瘤组织中肉瘤细胞发生不同程度的变性和坏死以及中性粒细胞、淋巴细胞为主的炎细胞浸润。Objective: Aim to investingate antineoplastic effect of Helleborus thibetanus Franch polysaccharose(HFPS) on murine sarcoma S180 and observe pathologic changes on thymus and sarcoma. Method:In these experiment,neoplasm model were established with S180 cell line.There were six experiment groups designed:normal control group,neoplasm model group,high dose of HFPS group,median dose of HFPS group,low dose of HFPS group and positive control group (treated with small dose of compound prescription Tian Xian capsule pill).The effect of HFPS on the growth of S180-bearing mice that were treated with HFPS gastric injected ,meanwhile, the thymus and neoplasm of every mice are prepared for obversition with light microscope.Result: The results showed that HFPS could limit the growth of S180 transplanted neoplasm in vivo;The result under microscope showed that HFPS may produce the cortex of thymus in S180-bearing mice thickened and the thymocytes and macrophages increased in number. HFPS can cause some pathologic change in tumor cells such as denaturation,necrosis .Conclusion:HFPS has the antineoplastic effect on S180 transplanted neoplasm in vivo and HFPS has promoting influences on the proliferation of lymphoid tissue or lymphcyte.

关 键 词：多糖 小鼠 瘤细胞 S180肉瘤 体内生长 胸腺组织 荷瘤鼠 筷子 抑制 变性 

分 类 号：R285[医药卫生—中药学]