地榆和虎杖鞣质抑制体内亚硝胺生成对抗巴豆油对皮肤的炎症反应和抗氧化作用的研究  

Antioxidant and Preventive Effect of Tannin onAcute Liver Toxicity lnduced by Aminopyrin and Sodium Nitrite

作　　者：傅乃武[1] 刘朝阳[1] 刘福成[1] 燕利学[1] 

机构地区：[1]中国医学科学院肿瘤研究所

出　　处：《中药药理与临床》1994年第2期13-16,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：小鼠口服地偷或虎杖鞣质２０ｍｇ／ｋｇ明显对抗氨基比林（ＡＰ）合并ＮａＮＯ２引起的急性肝损伤。小鼠耳部涂抹地榆或虎杖鞣质４ｍｇ，显著抑制巴豆油诱发的耳部肿胀。口服此两化合物１ｇ／ｋｇ／日，连服４天，也有效抑制巴豆油诱发的耳部肿胀。此两化合物２．５μｇ／ｍｌ明显抑制Ｏ２的产生。６０μｇ／ｍｌ显著对抗Ｈ２Ｏ２诱发的溶血。１６０μｇ／ｍｌ对羟自由基（’ＯＨ）有明显清除作用。AbstractTannin was eltracted from Sanguisorba Officinalis L. (SO) and Polygonum Cuspidatum Sieb et Zusc (PC). Oral administration of these two tannins 20mg/kg effectivelyprevented morose SGPT elevation induced by aminopyrin (AP) and sodium nitrite. WhenSO or PC was used locally or per oral, the mouse ear edema induced by croton oil wassignificantly inhibited. These two tannin had marked scayanging effect on O2 and 'OHproduction, and prevented against H2O2-induced hemolyses.

关 键 词：鞣质 虎杖 地榆 巴豆油 耳部 诱发 抑制 化合物 研究 NaNO2 

分 类 号：R282[医药卫生—中药学] R284[医药卫生—中医学]