葛根的抗肿瘤作用研究  

Anticancer Activity of Flos Puerariae

作　　者：杜德极[1] 石小枫[1] 冉长清[1] 起军宁 温志坚[1] 谢定成[1] 叶玉兰[1] 顾月翠[1] 

机构地区：[1]四川省中药研究所

出　　处：《中药药理与临床》1994年第2期16-20,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金

摘　　要：采用动物移植性瘤株ＥＣＳ癌、Ｓ１８０肉瘤、Ｌｅｗｉｓ肺癌等进行了葛根（ＦｌｏｓＰｕｅｒａｒｉａｅ）体内抗肿瘤作用的观察；用体视法观察了葛根对Ｌｅｗｉｓ肺癌的肺转移肿瘤组织形态上的变化；用体外同位素掺入法探讨了葛根三个品种的抗肿瘤作用。his paper is the first one to rport about anticancer activity of Flos puerariae (FP)in home and abroad. First of all, we investigated whether FP had anticancer effectagniest ECS carcinoma, S180 sarcoma and Lewis lung carcinoma (LLc) in Yivo.Futhermore, we obserAed the morphological chang of the lungs which LLc had metastasized toin C57BL/6 mice treated with FP. In addition, three genera of FP (9201, 9202, 9203)were compared in their antitumor activity bymeans of isotope incorghation assay in vitro.The results showed that FP extract at the dosage of 10g/kg ig for several days hada certainly inhibitory action against growth of ECS, S180 and LLc as well as a synergistic antitumor activity if combination with Cy or OK432 in vivo, and that all the threegenera at the concentration of 5 or 1mg/ml could inhibit significcantly proliferation ofP388 Leulcemia and W256 carcino sarcoma in vitro. However, 9202 and 9203 were moreactive than 9201.WW

关 键 词：抗肿瘤作用 葛根 LEWIS肺癌 瘤细胞 S180肉瘤 体外 小鼠 掺入法 研究 代号 

分 类 号：R285.5[医药卫生—中药学] R730[医药卫生—中医学]