白细胞介素-6及C-反应蛋白在慢性阻塞性肺疾病患者急性加重中的意义  

The significance of interleukin-6 and C-reactive protein in the exacerbation of chronic obstructive pulmonary diseases

作　　者：张冰[1] 王丹琪[1] 夏国光[1] 

机构地区：[1]北京积水潭医院呼吸科,北京100035

出　　处：《中国呼吸与危重监护杂志》2003年第2期85-86,共2页Chinese Journal of Respiratory and Critical Care Medicine

摘　　要：目的　探讨白细胞介素 6(IL 6)及C 反应蛋白 (CRP)在慢性阻塞性肺疾病 (COPD)急性加重过程中的意义。方法　对 32例COPD急性加重期患者治疗前、后及 30例健康成人外周血 ,采用双抗体ELISA法测定IL 6 ,散射比浊法测定CRP。结果　COPD急性加重期血清IL 6水平为 (31 2 4± 6 91 )ng/L ,治疗后为 (6 81± 1 53)ng/L ,治疗前较治疗后明显增高 (P <0 0 0 1 ) ;正常对照组IL 6为 (9 65± 1 64)ng/L ,与治疗后比较也有显著性差异 (P <0 0 5) ;COPD急性期CRP为 (1 0 6 8± 2 3 3)mg/L ,治疗后为 (9 42± 4 4)mg/L ,治疗前与治疗后比较有非常显著性差异 (P <0 0 0 1 )。结论　IL 6与CRP参与COPD的急性炎症过程 。Objective To study the implication of interleukin 6 (IL 6) and C reactive protein (CRP) in the exacerbation of chronic obstructive pulmonary diseases (COPD) Methods The serum was sampled and prepared from 32 cases of COPD patients with acute exacerbation before and after two weeks therapy and 30 normal controls Serum level of IL 6 was detected by ELISA and CRP by nephelometry method Results The level of IL 6 in COPD with acute exacerbation is significantly higher than that after therapy ( P <0 001) and lower than that in control group( P <0 05) The level of CRP in acute exacerbation is significantly higher than that in control group( P <0 001) Conclusion IL 6 and CRP are involved in the acute inflammation in COPD which may be indices of infection in COPD patients

关 键 词：白细胞介素-6 C-反应蛋白 IL-6 CRP 慢性阻塞性肺疾病 COPD 急性加重期 并发症 血清学检测 

分 类 号：R563.9[医药卫生—呼吸系统]