改性玻璃陶瓷在模拟体液中类骨磷灰石层形成的研究  

Study on Formation of Bone-like Apatite of BGC Modified by Cold Plasma in SBF

作　　者：苏葆辉[1] 冉均国[1] 苟立[1] 王方瑚[1] 

机构地区：[1]四川大学无机材料系,四川成都610065

出　　处：《生物医学工程研究》2003年第4期1-3,11,共4页Journal Of Biomedical Engineering Research

基　　金：国家重大基础研靠资助项目 ( 973G19990 6 4 76 0 )

摘　　要：研究用等离子体活化改性玻璃陶瓷 (BGC) ,并用模拟体液 (SBF)中类骨磷灰石的形成、体外成骨细胞培养、SEM、XPS、XRD等对其进行表征。结果表明 :与活化改性前相比较 ,等离子体活化改性后的BGC更有利于类骨磷灰石的形成 ,并能促进成骨细胞增殖。等离子体中丰富的高能、高活性的粒子轰击BGC ,使其被刻蚀和粗化 ,增加了表面的溶解性和提供了更多的活性位点 ,易使局域的钙、磷离子浓度达到过饱和 ,更利于类骨磷灰石的成核和生长。表明等离子体改性提高了BGC的生物活性。The surface modification using cold plasma technique was introduced to BGC.The study was showed by the formation of bone-like apatite in SBF and the results of osteoblast culture in vitro,SEM,SPS,XRD.The results showed that the formation of bone-like apatite on BGC modified by cold plasma was easier than that of without modification.The active mechanism is that impact on BGC by means of the particles with high energy and high activity led to the rough and etched surface of it, as well as the distortion of BGC crystal,which increase the dissolvability of BGC and the local concentration of the Ca and P ion.It is helpful for the formation of bone-like apatite.It is showed that the surface modification using cold plasma technique can increase the ctivity of BGC.

关 键 词：低温等离子体 改性玻璃陶瓷 BGC 模拟体液 SBF 类骨磷灰石 生物活性 

分 类 号：R318.08[医药卫生—生物医学工程] Q813.1[医药卫生—基础医学]