升血汤促进辐射后骨髓移植小鼠造血与免疫重建的研究  

Experimental Study on the Acceleration of the Hemato-Immunological Reconstitution of the Lethally IrradiatedMice Following Bone Marrow Transplantion( BMT ) by Sheng Xue Tang ( SXT)

作　　者：罗崇念[1] 王立为[1] 林新[1] 曹丽[1] 刘俭[1] 刘淑香[1] 赵扬[1] 谢蜀生[1] 肖培根[1] 

机构地区：[1]中国医学科学院中国协和医科大学药用植物研究所免疫室

出　　处：《中国实验动物学报》1996年第1期27-33,共7页Acta Laboratorium Animalis Scientia Sinica

摘　　要：本文用多项血液学及免疫学指标研究了中药升血汤对骨髓移植小鼠造血与免疫重建的影响，结果证明，升血汤有明显促进骨髓移植小鼠造血与免疫功能恢复的功效，表现在小鼠骨髓造血干细胞数量的恢复，小鼠外周血象的改善，脾及骨髓中有核细胞数的增加，明显促进小鼠细胞免疫和体液免疫功能的恢复，研究结果为升血汤的临床应用提供了实验依据。AbstractIn this paper, the effect of the Chinese traditional medicine-ShengXue Tang ( SXT ) on the hematological and immunological reconstitution ofBMT mice was studied.The results indicated that SXT can markedlyimprove the reconstitution of hematological and immunological functionsof BMT mice, including( 1 )the increase of CFU-GM, CFU-S and themononuclear cells in the spleen and bone marrow, the betterment ofperipheral blood counts, and particularly, the acceleration of the recons-titution of the cellular and humoral immune functions.The primary studysuggested that the enhancement of production of IL-2, the expression of IL-2 gene and the acceleration of the recovery of the ratio of CD4+/CDS8+

关 键 词：小鼠 骨髓移植 免疫重建 造血 临床应用 免疫学指标 有核细胞 数量 促进 恢复 

分 类 号：Q813[生物学—生物工程] R457.7[医药卫生—治疗学]