小剂量尿激酶治疗不稳定性心绞痛随机对照300例分析  

A Analysis on Randomed 300 Cases with Unstable Angina Treated in Lowdose Urokinase

作　　者：陶贵周[1] 李彦[2] 王健 袁荣玺[1] 高薇[1] 蒋朝利 

机构地区：[1]锦州医学院附属第一医院，锦州121001 [2]锦州市中心医院 [3]锦州市铁路中心医院 [4]不详

出　　处：《现代康复》1999年第1期85-86,共2页Modern Rehabilitation

摘　　要：目的：为了探讨小剂量尿激酶（ＵＫ）对不稳定心绞痛（ＵＡ）的疗效及对ＵＡ发生急性心肌梗塞（ＡＭＩ）和心源性猝死（ＳＣＤ）作用。方法：对３００例ＵＡ患者随机分成溶栓治疗组和对照组（常规治疗组），其中３０例经冠造证实。结果：溶栓治疗组疗效明显高于对照组。溶栓治疗组ＡＭＩ和ＳＣＤ发生率明显低于对照组。同时发现初发性、恶化性、梗塞后和中间综合征的疗效明显高于静息性和混和性ＵＡ（Ｐ＜０．０１）。冠造结果发现：心电图（ＥＣＧ）ＳＴ段抬高的ＵＡ病人血栓出现率明显高于ＳＴ段下移的病人（Ｐ＜０．０１）。结论：小剂量ＵＫ治疗ＵＡ疗效好且无明显副作用。Objective:Recently,thrombosis and plaque rupture have been demostrated the most important pathogenetic mechanisms.Nevertheless,Clear-cut results on the effects of thrombolytic therapy in unstable angina are still lacking.Methods:300 patients were divided randomly into two groups.150 cases in thrombolytic group urokinaes(UK),and 150 cases in contrast(conventional therapy).Results:Notable efficency is 40% versus 17.3%(P<0.01)respectively.Total effective is 79.3%.versus 65.3%(P<0.01).Conclusion:Low dose UK can significantly decrease the incidence of new adverse cardiacevents.It also demostrated that the effectiveness on Initial、progressive、Variant Angina and Intermidiate syndrom were significantly greater than rest and blending angina(P<0.01).There is no any fatal side-effect in all the patients.

关 键 词：不稳定性心绞痛 尿激酶 溶栓治疗 冠状动脉造影 小剂量 

分 类 号：R541.4[医药卫生—心血管疾病] R973.2[医药卫生—内科学]