围生儿垂体─性腺轴系功能的研究  

Study of pituitary-gonadol axis function in neonates during the first 7 days of life

作　　者：银寿春[1] 洪茜萍[1] 毕道濯[1] 陶枫[1] 马堪悦[1] 刘金玲[1] 徐士杰[1] 

机构地区：[1]天津医学院附属医院儿科教研室,天津医学院附属医院妇产科放免室

出　　处：《中国优生与遗传杂志》1994年第3期30-32,共3页Chinese Journal of Birth Health & Heredity

摘　　要：本研究以放免法测定脐血清Ｅ２水平，男ｘ＝２０．１４±７．９８ｎｍｏｌ／Ｌ和女ｘ＝２４．７７±８．８３ｎｍｏｌ／Ｌ。ｔ检验性别间无显著性差异。末梢血清生后男女均急剧下降至０．０３±０．０１ｎｍｏｌ／Ｌ，整个围产期持续低。Ｔ脐血清水平男ｘ＝３．０７±１．１６ｎｍｏｌ／Ｌ，女ｘ＝２．３６±０．７４ｎｍｏｌ／Ｌ，无性别差异。女婴生后末梢血清一直在低水平，而男婴则迅速上升，一日左右高峰值８．４５±２．５５ｎｍｏｌ／Ｌ，５日后又复下降。有明显性别差异，在１和３天时Ｐ分别是０．００１和０．０１。生后胎盘源激素被大量清除，导致下丘脑－垂体－性腺轴系激活；Ｔ于生后急剧上升，显示生成增加，睾丸Ｌｅｙｄｉｇ细胞被迅速激活；均提示围生儿垂体－性腺轴系趋于成熟。The postnatal pituitary-gonadol axis function of neonate boys and girls was studied by meassu rments of serum estradiol and testosterone in cord sera and in peripheral sera on 0-7 days of postnatal age,In cord serum ofmale and female neonates mean estradiol level was 20.14±7.98 nmol/L and 24.77±8.83 nmol/L,respectively,No significant sex difference was seen,After birth there was a rapid fall in serum estradiol level of 0.03±0.01 nmol /L,lasting low for whole perinatal period.Testosterone level in cord serum of male and female neonates mean 3.07±1.16 nmol/L and 2.36±0.74 nmol/L was found, repectically, No sex difference was seen,After birth there was constantly low in serum testosterone level in female neonates,but there was a dramatically rise in male neonates,up to peak level of 8.45±2.55 nmol/L on day l,and decreasing 5 days later.There was significant sex difference,P value was 0.00l and 0.0l on day 1 and day3,respevtively. The elimination of placental steroid estradiol at birth is largely responsible for the postnatal activation of the hypothalamic-pituitary-gonadol axis.The present study clearly documents a large increase in testosterone in serum during the first 5 days,suggesting the rapid activition of the testes Leydig cell and the maturity of the axis.

关 键 词：脐血清 围生儿 垂体 性腺轴 末梢血 激活 放免法测定 水平 性别差异 上升 

分 类 号：R714[医药卫生—妇产科学] R446[医药卫生—临床医学]