血管紧张素转换酶抑制剂和β-受体阻断剂对冠心病患者心率变异性的影响  

The Effects of ACEI and β-Blocker on Heart Rate Variability in Patients with Coronary Artery Disease

作　　者：韩君勇[1] 黄达梅[1] 周元植[1] 张莉[1] 

机构地区：[1]贵阳医学院附院心内科,贵州贵阳550004

出　　处：《贵阳医学院学报》2001年第6期487-489,共3页Journal of Guiyang Medical College

摘　　要：目的 :观察血管紧张素转换酶抑制剂和 β 受体阻断剂用药前后冠心病患者心率变异性 (HRV)的变化 ,以探讨血管紧张素转换酶抑制剂和β 受体阻断剂对冠心病人HRV的影响及机理。方法 :将 93例冠心病人根据用药情况分为 3组 ,C1组 :服用消心痛 +阿司匹林 ;C2组 :服用消心痛 +阿司匹林 +卡托普利 ;C3组 ;服用消心痛 +阿司匹林 +倍他乐克 (或阿替洛尔 )。观察用药前后全天HRV变化。结果 :C1组用药前后R -R连续差异平方根 (rMSSD)、高频能谱 (HF ,ms2 )、低频能谱 (LFms2 )和LF/HF差异无显著意义 (P >0 0 5 )。C2组用药前后比较 ,rMSSD为 2 5 3 7± 11 87和 3 6 68± 12 2 3 ,HF为 170 78± 10 8 80和 196 3 4± 10 8 77,LF/HF为2 0 9± 1 3 7和 1 75± 1 0 6,rMSSD、HF试验后比试验前明显升高 ,差异有极显著意义 (P <0 0 1) ;LF/HF降低 ,差异有显著意义 (P <0 0 5 )。C3组用药前后rMSSD为 2 8 97± 11 71和 3 3 2 9± 10 77,HF为 15 5 3 1± 10 1 2 5和 2 14 42± 12 0 77,LF为 3 0 2 79± 2 11 2 4和 3 3 5 40± 2 0 8 82 ,LF/HF为 2 5 1± 1 62和 1 83± 1 2 2。rMSSD、HF在试验后比试验前明显升高 ,差异有极显著意义 (P <0 0 1) ;LF升高 ,差异有显著意义 (P <0 0 5 ) ;LF/HF明显降低 ,差?Objective: We have observed the changes of heart rate variability (HRV) in patients with coronary artery disease before and afrer treatments in order to determine the effects of angiotensin-converting enzyme inhibitors (ACEI)and β-blocker on HRV. Methods: HRV in the whole day was assessed and HRV(rMSSD,LF,HF)was obtained from 93 patients with coronary artery disease before and after treatments. Of them 30 patients treated with sorbitrate and aspirin (group C1), 32 patients treated with sorbitrate, aspirin and captopril (group C2), and 31 patients treated with sorbitrate, aspirin and metoprdol or atenolol (group C3). Results: ACEI increased rMSSD from 25 37±11 87 to 36 68±12 23(P<0 01),HF from 170 78±108 80 to 196 34±108 77(P<0 01),decreased LF/HF from 2 09±1 37 to 1 75±0 06(P<0 05) after treatments in gruop C2 β-blocker increased rMSSD from 28 97±11 71 to 33 29 ±10 77, HF form 155 31±101 25 to 214 42±120 77(P<0 01),LF form 302 79 ±211 24 to 335 40 ± 208 82(P<0 05) and decreased LF/HF from 2 15±1 62 to 1 83±1 22(P<0 01)in group C3 The changes of HRV in group C1 were not statistically significant. Conclusion: ACEI and β- blocker could improve the balance of autonomic nervous activties in patients with coronary artery disease.

关 键 词：血管紧张素转换酶抑制剂 Β受体阻断剂 冠状动脉疾病 心率变异性 

分 类 号：R541.4[医药卫生—心血管疾病]