维生素E减轻阿霉素心脏毒性的实验研究  

STUDY ON EFFECT OF VITAMIN E IN REDUCING DOXORUBICIN-INDUCED CARDIOTOXICITY

作　　者：朱永廉[1] 耿宝琴[1] 王金茂[2] 

机构地区：[1]浙江医科大学药理学教研室 [2]浙江医科大学组织胚胎学教研室

出　　处：《浙江医科大学学报》1993年第4期145-147,共3页

基　　金：浙江省自然科学基金

摘　　要：40只NIH小鼠分为单用阿霉素20mg/kg、两种不同剂量维生素E分别合用阿霉素、以及对照共4组。合用维生素E组小鼠存活时间显著长于单用阿霉素组小鼠,病理切片光镜检查结果显示,合用维生素E组小鼠心肌病变程度显著减轻。本实验结果提示维生素E能减轻阿霉素引起的小鼠心脏毒性。40 NIH mice were treated with 20mg/kg of doxorubicin ip with and without vitamin E to examine the effect of vitamin E on doxorubicin-induced cardiotoxicity. Coadministration of vitamin E resulted in prolongation of survival period. The light microscopic examination of myocardial tissue from the mice treated with both doxorubicin and vitamin E revealed a marked diminution of vacuolization. The results suggest that vitamin E is effective in redu- cing doxorubicin-induced cardiotoxicity in mice.

关 键 词：维生素E 阿霉素 毒性 心肌 

分 类 号：R969.2[医药卫生—药理学]