大鼠胚泡着床前应用阿司匹林和醋氨酚对仔鼠的行为致畸作用  

BEHAVIORAL TERATOGENICITY IN THE OFFSPRINGS OF RATS TREATED WITH ASPIRIN OR ACETAMINOPHEN DURING PREIMPLANTATION

作　　者：应赢[1] 楼宜嘉[1] 刘鹤雏[1] 

机构地区：[1]浙江医科大学药学系药理教研室

出　　处：《浙江医科大学学报》1993年第5期196-198,共3页

摘　　要：大鼠于妊娠第3天分别用阿司匹林(Asp)500mg/kg或醋氨酚(Ace)1000mg/kg灌胃,仔鼠出生后作生理功能和行为试验。结果表明,Ace 1000mg/kg组仔鼠出生后最初9天的体重显著较轻,门齿萌发和听觉出现延缓,游泳能力和学习记忆能力均显著低于对照组:Asp 500mg/kg组除游泳能力低于对照组外,其它各项指标均与对照组无统计学差异。Previous studies have shown that preimplantation treatment with aspirin or acetaminophen markedly inhibited the development of blastocysts in rats and embryotoxicity and teratogenicity were also found during the examination of their fetuses. The present study was designed to ex- amine effects on the development of physiological function and behaviour in their offsprings. Pregnant rats were treated with either 500mg/kg of aspirin or 1000mg/kg of acetaminophen on the third gestational day (positive vaginal smear=day 0), and their offsprings were evaluated postnatally through physiological examinations and neurobehavioral tests. The results showed that difference between acetaminophen and the control group was discovered in body weight, in- cisor eruption, auditory startle, swimming performance and Y-water maze. The aspirin group reduced only the swimming ability of the offsprings. These data revealed that acetaminophen causes marked retardation of postnatal growth and behavioral toxicity to the offsprings of rats treated before implantation.

关 键 词：阿司匹林 醋氨酚 药物副作用 

分 类 号：R965.3[医药卫生—药理学]