血清和肝组织内HBV复制状态与肝脏病变活动性关系的研究  

STUDY ON RELATIONSHIP BETWEEN SERUM AND LIVER HBV REPLICATION AND HEPATIC HISTOPATHOLOGIC CHANGES IN PATIENTS WITH HEPATITIS B

作　　者：刘克洲[1] 陈智[1] 章明太[1] 丁列明[1] 金建华[1] 余乾炎 张秀芝[1] 陈明华[1] 陈慰浙[2] 方淑娟[2] 何文南[3] 张金龙[3] 

机构地区：[1]浙江医科大学传染病研究所 [2]浙江医科大学附属第一医院病理科 [3]浙江省武警部队总医院

出　　处：《浙江医科大学学报》1993年第6期264-267,共4页

摘　　要：经病理确诊的47例乙型肝炎患者血清中HBV DNA、HBeAg的检出率在各型肝炎之间无显著性差异(P>0.05)。肝组织HBsAg检出率为76.6％,其形态呈包涵体型、弥漫型和膜型为主分布者分别是36.1％、55.6％和8.3％。HBsAg呈弥漫型分布者各类型肝炎之间无显著性差异(P>0.05),提示肝细胞内HBsAg的表达仅反映HBV复制,而与肝组织病变无关。肝组织HBcAg检出率为27.7％,其形态呈核型和浆型分布者分别占38.5％和61.5％,浆型主要见于炎症明显的肝细胞内,而核型刚见于病变较轻的肝细胞中,反映了HBcAg的表达与肝组织活动性病变有关。Serum HBV DNA, HBeAg and intrahepatic distribution and morphology of HBsAg, HBcAg in relation to histopathologic changes in liver tissues were observed in 47 patients with hepatitis B. No significant difference was found between the positive rates of serum HBeAg and HBV DNA among different clinical types of hepatitis B (P>0.05). HBsAg was detected in the liver tissue of 76.6％ patients with inclusion body, diffuse or membranous patterns (36.1％, 55.6％ and 8.3％ respectively). No significant difference was found among the different types of hepatitis B with HBsAg diffuse pattern in the liver tissues (P>0.05), which indicated that the intrahepatic expression HBsAg reflected only the replication of HBV DNA, and had no rela- tion to pathologic changes. HBcAg was found in hepatocytes of 27.7％ patients with the mor- phology of nuclear and cytoplasmic patterns (38.5％ and 61.5％ respectively). The cytoplasmic pattern was mainly found in hepatocytes with active inflammation and the nuclear pattern in he- patocytes with mild inflammation, indicating a correlationship between HBcAg expression in hep- atocytes and active pathological changes.

关 键 词：乙型肝炎病毒 抗原 病理学 

分 类 号：R512.620.3[医药卫生—内科学]