不同频率对关节炎大鼠痛反应及中枢γ—氨基丁酸和谷氨酸含量的影响  

EFFECTS OF ELECTROACUPUNCTURE AT DIFFERENT FREQUENCIES ON THE NOCICEPTIVE RESPONSE AND CENTRAL CONTENTS OF GABA AND GLUTAMIC ACID IN ARTHRITIC RATS

作　　者：曹蔚鸿[1] 邓颖[1] 董晓彤[1] 王友京[1] 陆卓珊[1] 

机构地区：[1]中国中医研究院针灸研究所,北京100700

出　　处：《针刺研究》1993年第1期48-52,共5页Acupuncture Research

摘　　要：电针在急性关节炎动物模型上有镇痛作用,但不同电针参数的研究未见报道。本实验用100赫芝和15赫芝两种频率电针关节炎大鼠阳陵泉穴,可见低频电针镇痛效应优于高频电针;低频电针组脊髓谷氨酸含量低于高频电针组,γ-氨基丁酸含量在两组间无明显著差别。结果提示脊髓谷氨酸可能与不同频率电针的镇痛效应有密切关系。It has been demonstrated that electroacupuncture (EA) produces analgesiain acute arthritic animal models,while the differential analgesic effects at dif-ferent EA parameters remains to be discovered.In the present experiment,theeffects of EA at 100 Hz and 15 Hz on bilateral Yanglingpuan acupoints of thearthritic rats was studied.The results showed:1) 15Hz EA was more effectivethan 10Hz EA for analgesia;2) spinal glutamic acid content of the 15-Hz EAgroup was significantly lower than that of the 100-Hz EA group,and 3) nosignificant difference in GABA contents between the two groups was found.The results suggest that spinal glutamic acid may be involved in the differentanalgesic effects of EA at different frequencies in arthritic rats.

关 键 词：氨基丁酸 关节炎 痛反应 电针 

分 类 号：R245.97[医药卫生—针灸推拿学]