毁损运动皮层对体感Ⅱ区下行调节丘脑髓板内核群作用的影响  

fluence of Lesion of Motor Cortex on Second Somatosensory Area manating Descending Modulation on Thalamic Intralaminar Nuclei

作　　者：陈正秋[1] 郑欣[1] 石宏[1] 徐维[1] 

机构地区：[1]中国中医研究院针灸研究所,北京100700

出　　处：《针刺研究》1993年第3期183-188,共6页Acupuncture Research

基　　金：图家自然科学基金

摘　　要：用玻璃微电极细胞外记录丘脑髓板内核群(ILN)神经元放电的方法,观察到:毁损运动皮层使电刺激体感Ⅱ区(SII)抑制ILN 神经元伤害性反应的效应减弱;当毁损涉及某些深部结构时,电刺激 SII 对 ILN 神经元的伤害性反应呈易化效应。进一步证明SII 对 ILN 神经元下行性调节有部分是通过运动皮层实现的。The present study was undertaken to verify further the participation of motor cortex(MCtx)in the somatosensory area Ⅱ(SII)emanating descending modulation of thalamic intralam-inar nuclei(ILN).Neuronal responses in ILN to noxious stimulation of the superficial peroneal nerve were ex-tracellularly recorded in 34 cats.The effects of electrical stimulating SII on nociceptive responsesof neurons in ILN before and after lesion of MCtx were observed and compared.It was shown that electrical stimulation of SII obviously inhibited the nociceptive responsesin the majority of neurons recorded(11/13)in ILN in the cats with MCtx intact(P<0.05).Afterlesion of MCtx the inhibitory effect still remained(n=10,P<0.05),but weakened to a certainextent compared with that before lesion.In the animals with the lesion involving MCtx and theunderlying subcortical structures electrical stimulating SII facilitated the nociceptive responses ofILN neurons(n=7,P<0.05).The results further support the idea that SII emanating descending modulation on ILN is inpart fulfiled via MCtx.

关 键 词：伤害性反应 运动皮层 ILN 体感区 

分 类 号：R245[医药卫生—针灸推拿学]