敌枯双对猕猴毒性作用的观察  

Studies for the toxicity of N,N'-methylene-bis-(2-amino-1,3,4-thia-diazole) in rhesus monkeys.

作　　者：李来玉[1] 傅立杰[2] 谢文桂[3] 闭中强[3] 杨洁芳 顾学箕[4] 

机构地区：[1]广东省职业病防治院,广州市怡乐路510260 [2]江西医学院卫生系 [3]广西壮族自治区职业病防治研究所 [4]上海医科大学劳动卫生学教研室

出　　处：《职业医学》1993年第4期200-201,共2页China Occupational Medicine

摘　　要：敌枯双[N,N’-methylerie-bis-(α-amino-1,3,4-thiadiazole)、(MATDA)]以静脉注射、灌胃和喂饲给妊娠与雌、雄性猕猴染毒。结果:除喂饲组外,猕猴表现摄食差,萎靡和活动减少,进而呕吐、拒食和腹泻;孕猴出现流产或仔猴畸形;甲状腺病理变化明显,从滤泡增生至抑制,具剂量—反应关系。Pregnant and nonpregnant rhesus monkeys were administered by intravenous injection, garage or feeding respectively with N, N'-methylene-bis-(2-amino-1, 3, 4-thiadiazole) (MATDA). Dispirit, reducing food intake, vomiting, diarrhea, abortion, fetal malformation and proliferation or inhibition of folliculi glandulae thyreoideae were shown in monkeys treated by intravenous injection and garage. The above toxicological responses also showed a significant dose-response relationship. No abnormal effects were observed in those monkeys fed with MATDA.

关 键 词：敌枯双 猕猴 毒性 甲状腺 

分 类 号：R139.3[医药卫生—劳动卫生]