尿乳酸肌酐比值测定与新生儿缺氧缺血性脑病的研究  

Measurement of Ratio of Urinary Lactate and Creatinine Ratio for Studying Hypoxic-ischemic Encephalopathy of Newborn Infants

作　　者：刘韧[1] 何素蓉[1] 李光富[1] 于晓[1] 

机构地区：[1]四川省宜宾市二医院,四川宜宾644000

出　　处：《四川省卫生管理干部学院学报》2002年第1期8-8,47,共2页Journal of Sichuan Continuing Education College of Medical Sciences

摘　　要：目的 :研究尿乳酸肌酐比值对早期识别新生儿围产期窒息及缺氧缺血性脑病的诊断价值。方法 :通过测定76例新生儿 (正常 3 7例 ,异常 3 9例 )出生后 6小时内尿乳酸与肌酐的比值 ,并用阿普伽评分等指标判断新生儿神经、呼吸系统情况 ,分析尿乳酸肌酐比值与新生儿缺氧缺血性脑病的关系。结果 :正常新生儿的尿乳酸肌酐比值是 0 0 0 2 8,窒息儿的尿乳酸与肌酐的比值是 0 0 0 60 ,是正常新生儿的 2倍 ,缺氧缺血性脑病的是 0 3 3 2 9,是正常新生儿的 115倍 (P <0 0 0 1) ,是单纯窒息儿的 5 5倍 (P <0 0 0 1)。结论 :尿乳酸肌酐比值对于临床早期预测判断新生儿缺氧缺血性脑病 ,对于儿科医生早期介入治疗是很有价值的。Objective:To Study the diagnostic value of the ratio of urinary lactate and creatinine for newborn infants with perinate asphyxia and hypoxic-ischemic encephalopathy. Method: Measured the ratio of lactate and creatinine in urine within 6 hours after birth in 37 normal infants and 39 abnormal infants. Result:The lactate: Creatinine ratio of normal newborn infants was 0.0028, Asphyxia infants was 0.0060. Hypoxic-ischemic encephalopathy infants was 0.3329. Conclusion: Measurement of the ratio of urinary lactate and creatinine early after birth may help identify hypoxic-ischemic encephalopathy in infants at high risk.

关 键 词：尿乳酸 尿肌酐 新生儿 缺氧缺血性脑病 

分 类 号：R722[医药卫生—儿科]