三硝基甲苯中毒性肝病的血清透明质酸结合甘胆酸含量分析  

Analysis of serum HA and CG concentrations in the patients with TNT poisoning.

作　　者：冯学庆[1] 施荣山[1] 叶林[1] 王心箴[1] 

机构地区：[1]安徽省职业病防治研究所,合肥市绩溪路230022

出　　处：《职业医学》1993年第6期328-329,共2页China Occupational Medicine

摘　　要：本文对慢性病毒性肝炎、TNT中毒性肝病患者进行了血清HA、CG的实验研究,发现中毒性肝病组HA、CG含量分别为267.42μg/L和16.22μmol/L,慢性病毒性肝炎组为700.62μg/L和36.97μmol/L;正常对照组仅为89.47μg/L和3.70μmol/L。HA、CG诊断TNT中毒的敏感度分别为62.5%和75.0%,特异度为88.3%和75.5%,二者结合使用可使敏感度与特异度分别提高到87.5%和95.7%。结果表明,HA、CG同时使用,不仅能辅助诊断TNT中毒性肝损伤,而且与慢性病毒性肝病的鉴别诊断也有较大的应用价值。Serum hyaluronic acid (HA) and cholylglycine (CG) concentration were examined in serum samples from 18 patients with viral hepatitis and 8 patients with TNT poisoning. It showed that the average concentrations of HA and CG in patients from TNT poisoning were 267.42 μg/L and 16.23 μmol/L respectively; and 700.62 μg/L and 36.97 μmol/L in the patients from viral hepatitis; and 89.47 μg/L and 3.7 μmol/L in the control group. Sensitivity of serum HA and CG concentration for TNT poisoning were 62.5% and 75.0% respectively; specificity 88.3% and 75.5%. An increased sensitivity and specificity 87.5% and 95.7% respectively were observed at combining use of those HA and CO concentrations. The results showed that serum HA and CG concentrations could be used as a diagnostic index for TNT poisoning, as well as differentiating index for viral hepatitis and TNT hepatic damage.

关 键 词：中毒性肝病 鉴别诊断 梯恩梯 CG HA 

分 类 号：R598.1[医药卫生—内科学]