系统性红斑狼疮患者血清泌乳素水平的前瞻性研究  

Prospective study on serum levels of prolactin in patients of systemic lupus erythematosus

作　　者：李锋[1] 冯树芳[1] 徐金华[1] 陆云[2] 邓守贞[2] 

机构地区：[1]复旦大学医学院附属华山医院皮肤科,200040 [2]复旦大学医学院附属华山医院核医学科,200040

出　　处：《中国药物与临床》2001年第1期7-9,共3页Chinese Remedies & Clinics

基　　金：国家自然科学基金资助项目(39770688)

摘　　要：目的 探讨系统性红斑狼疮（ＳＬＥ）患者血清泌乳素（ＰＲＬ）水平与ＳＬＥ活动期的关系。方法 应用时间分辨免疫发光试验（ＴｒＦＩＡ）测定１１３例ＳＬＥ患者和３０名正常人血清ＰＲＬ水平，ＥＬＩＳＡ测定血清ＩＬ－２Ｒ的浓度，用ＳＬＥＤＡＩ评估了１１３例ＳＬＥ患者的病情活动性以及Ｌｏｇｉｓｔｉｃ多元回归研究临床表现、免疫学指标与高ＰＲＬ血症的关系。结果６３例ＳＬＥ活动期患者血清ＰＲＬ水平（１４±７）μｇ／Ｌ显著高于５０例静止期患者（１２±８）μｇ／Ｌ和３０名正常对照组（７±６）μｇ／Ｌ；７４．９％的活动期患者血清ＰＲＬ水平在９－５１．２μｇ／Ｌ；１１３例ＳＬＥ患者血清ＰＲＬ水平与ｄｓＤＮＡ抗体、ＳＬＥＤＡＩ呈线性正相关 ；Ｌｏｇｉｓｔｉｃ多元回归研究发现蛋白尿、低Ｃ３和高ｄｓＤＮＡ抗体滴度与高ＰＲＬ血症相关。结论ＳＬＥ患者血清ＰＲＬ轻度升高与ＳＬＥ的病情活动性相关。Objective To study the association of serum prolactin (PRL) levels with the disease activity in the patients of systemic lupus erythematosus (SLE). Methods The author measured serum PRL levels with time-resolved fluoroimmunoassay (TrFIA) in 113 patients of SLE and in 30 gender-aged-paired controls, estimated SLEDAI, investigated the association of clinic, immunologic index and high anti-dsDNA antibodies titers with hyperprolactinemia by logistic regression in 113 patients of SLE. Results The serum PRL levels of 63 active patients are higher than that of 50 inactive patients and that of 30 control subjects. The serum PRL levels are ranging 9-51.2μg/L in 79.3 percent active patients. 50% patients in active group are in 15 51 .2μg/ L. It is also found that PRL level was linearly positively related to anti-double strand DNA antibodies titers. The concentration of interleukin 2 receptors in hyperprolactinemia group is higher than that of normal group. Logistic regression showed that proteinuria, low levels of complement 3 and high anti-dsDNA antibodies titers correlate with hyperprolactinemia. Conclusion The milidly elevated serum levels of PRL are associated with activity of SLE.

关 键 词：PRL 患者 SLEDAI 血清泌乳素 系统性红斑狼疮 活动期 病情活动 DNA 水平 人血清 

分 类 号：R593.241[医药卫生—内科学] R758[医药卫生—临床医学]