烧伤中分子物质对豚鼠心肌线粒体膜流动性影响的实验研究  

Experimental study on effect of plasma middle molecules produced by burn on membrane fluidity of myocardic mitochondria in guinea pigs

作　　者：董为人[1] 王铁丹[1] 肖应庆[1] 王东海[1] 叶本兰[2] 肖家思[2] 

机构地区：[1]第一军医大学,广州510515 [2]第三军医大学

出　　处：《中国病理生理杂志》1993年第3期404-407,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金

摘　　要：本文应用从正常和烧伤豚鼠血中提取的中分子物质(NMMS,BMMS),以不同浓度干扰豚鼠心肌线粒体,观察中分子物质对线粒体膜流动性的影响。结果表明,NMMS和BMMS,尤其是BMMS在一定浓度下显著抑制膜流动性。作者认为,BMMS参与了烧伤后心泵功能障碍的病理机制。The effect of plasma middle-molecule substances produced by burn (BMMS) at various concentrations on membrane fluidity of myocardic mitochondria of guinea pigs was studied and was compared with that of normal middle-molecule substances (NMMS). The result showed that, the membrane fludity of myocardic mitochondria was significant- ly decreased when it was incubated with either NMMS or BMMS at certain levels, espe- cially signficant with the latter. It was suggested that BMMS may play an important role in cardiodepression in thermal trauma.

关 键 词：毒素 心肌 线粒体 荧光分析 烧伤 

分 类 号：R644[医药卫生—外科学]