心理应激的免疫抑制作用及其与神经内分泌反应的相关性  

THE EFFECT OF EMOTIONAL STRESS ON THE PRIMARY HUMORAL IMMUNITY OF RATS: INTERACTION WITH THE SYMPATHETIC NERVOUS SYSTEM

作　　者：邵枫[1] 林文娟[1] 王玮雯[1] 

机构地区：[1]中国科学院心理研究脑-行为研究中心,北京100101

出　　处：《心理学报》2001年第1期43-47,共5页Acta Psychologica Sinica

基　　金：中国科学院重点基金;创新工程基金!(KSCX2-2-03);国家自然科学重点基金!(39830130)

摘　　要：以给予经定时喂水训练大鼠空瓶刺激为情绪性心理应激源，研究了此情绪应激对大鼠特异性原发体液免疫反应的影响及其可能的作用机制。结果表明每次10分钟，共14次的情绪应激显著降低大鼠抗特异性抗原OVA的抗体水平及脾脏指数，而显著增高血肾上腺素、去甲肾上腺素和皮质酮水平。研究还发现去甲肾上腺素与抗特异性抗原OVA的抗体水平呈显著负相关。该研究证实了情绪性心理应激对大鼠体液免疫功能的抑制作用，并提示交感神经系统可能参与了此免疫调节作用。The effect of exposure to emotional stress on the primary humoral immune fun ction(antiovallum antibody level and spleen index), the endocrine response (cort icosterone level, epinephrine and norepinephrine levels), the behavioral changes (exploring, grooming and attacking behavior) was studied in adult male Wistar r ats. Emotional stress was induced by randomly giving empty water bottles to rats trained to drink water at two set times each day. Emotional stress were given 1 4 times, ten minutes per each time during experimental period. Results showed th at firstly, empty water bottles induced significant attacking behavior (biting t he empty water bottle and cage shed) in rats of emotional stress group, secondly emotional stress decreased the weight of the spleen and the level of specific a nti-OVA IgG antibody and increased the levels of epinephrine, norepinephrine and corticosterone. A negative correlation between antibody levels and level of nor epinephrine was also found. Together with the previous work in our laboratory, t he results demonstrated that emotional stress suppressed the specific primary hu moral immunity of rats. The sympathetic nervous system may be involved in this immunomodulation.

关 键 词：情绪应激 原发体液免疫反应 交感神经系统 

分 类 号：B845[哲学宗教—心理学]