卡托普利抗自由基作用及其免疫活性  

Effects of captopril on free radical production and it's immune function

作　　者：王兴旺[1] 顾维戎[1] 夏叶玲 金巧秀[1] 

机构地区：[1]扬州医学院药理学教研室

出　　处：《中国病理生理杂志》1993年第2期220-223,共4页Chinese Journal of Pathophysiology

摘　　要：卡托普利(CPT,40,80mg/kg,ig)可提高小鼠血清超氧化物歧化酶活性,并减弱酵母多糖激发的小鼠腹腔巨噬细胞鲁米诺依赖的化学发光。CPT(160mg/kg,ig)可降低小鼠血清过氧化脂质含量。用MTT颜色反应法还观察到,CPT(25μg/ml)在体外可抑制刀豆素A诱导的小鼠脾淋巴细胞增殖反应。CPT的上述作用可能是其治疗免疫性疾病的重要机理。Captopril (CPT, 40, 80mg/kg, ig) enhanced serum superoxide dismutaseactivity, and suppressed luminal-dependent chemiluminescence of peritoneal macrophagesin mice. CPT (160mg/kg, ig) had a suppressive action on lipid peroxidation of mice. Theseresults suggested that CPT had antioxygen free radical effect or anti-lipid peroxidationeffects. CPT at 25 μg/ml concentration suppressed ConA-induced prolifeation of mousesplenic T lymphocytes in vitro, which suggested that CPT had a suppressive effct on Tlymphocyte function.

关 键 词：卡托普利 过氧化脂质 超氧物歧化酶 

分 类 号：R972[医药卫生—药品]