钙通道阻滞剂对巨噬细胞源性生长因子刺激平滑肌细胞增生的抑制作用  

The inhibitory effects of calcium-channel blockers on tne growth of SMC stimulated by MDGF

作　　者：李慧丽[1] 张彩英[1] 黄桂秋[1] 徐德敏[1] 张健[1] 

机构地区：[1]上海第二医科大学病理生理教研室,上海200025

出　　处：《中国病理生理杂志》1993年第2期231-235,共5页Chinese Journal of Pathophysiology

摘　　要：培养的家兔腹腔巨噬细胞分泌巨噬细胞源生长因子(macrophage-derived growth factor,MDGF),可刺激平滑肌细胞(smooth muscle cells,SMC)增生,经用钙通道阻滞剂作用于被MDGF刺激的SMC,则其增生反应即被明显抑制(P<0.05)。Cultured rabbit peritoneal macrophages could produce and secrete a growth-stimulatory factor (MDGF) that could stimulate the growth of cultured SMC in vitro(P<0.05); while calcium channel blockers (verapamil and nifedipine) could inhibit the pro-liferation of SMC stimulated by MDGF (P<0.05).

关 键 词：细胞 钙拮抗剂 动脉粥样硬化 

分 类 号：R543.502[医药卫生—心血管疾病]