家犬油酸性急性肺损伤时的血液流变学变化  

Hemorheologic changes during acute lung injury induced by oleic acid on dogs

作　　者：崔希忠[1] 徐隆绍[2] 

机构地区：[1]潍坊医学院病生教研室,潍坊261042 [2]天津医学院病生教研室

出　　处：《中国病理生理杂志》1993年第3期383-386,共4页Chinese Journal of Pathophysiology

摘　　要：本文观察了家犬油酸性急性肺损伤时红细胞的聚集性及相关指标。结果发现,红细胞聚集指数、红细胞压积、血浆镁显著增加,纤维蛋白(原)降解产物浓度显著升高;而纤维蛋白原、血浆钙和红细胞内镁明显减少。注射油酸后红细胞在自身血浆中的电泳时间明显延长,而在PBS中的电泳时间在360min时才显著延长。逐步回归分析提示,对红细胞聚集影响最大的因素是红细胞压积、红细胞内镁和红细胞表面电荷的变化。Erythrocyte aggregation and related parameters were observed in this study. Erythrocyte aggregation index, hematocrit and fibrin fibrinogen degradation products in- creased significantly at 5 minutes after oleic acid injection. Erythrocyte electrophoretic time in native plasma delayed obviously at 5 minutes after oleic acid injection, whereas that in PBS altered very little. The concentration of plasma calcium and erythrocyte intracellular magnesium decreased at 5 minutes, while plasma magnesium increased. The stepwise reg- ression analysis suggested that during lung injury the parameters that have greatest effect on erythrocyte aggregation were the change of hematocrit, erythrocyte intracellular magnesium and negative charge of erythrocyte surface.

关 键 词：肺 油酸类 红细胞聚集 血液流变学 

分 类 号：R331.3[医药卫生—人体生理学]