声门外高频喷射通气对失血性休克狗血气和脂质过氧化的影响  

Effects of HFJV outside of the glottis on the blood gas and lipid peroxidation in dogs with hemorrhagic shock

作　　者：史玉梅[1] 黄学顺[1] 刘秋如[1] 黎曰真[1] 吴吉茂 吴绮明[2] 

机构地区：[1]江西医学院病理生理教研室,南昌330006 [2]江西医学院病理解剖教研室,南昌330006

出　　处：《中国病理生理杂志》1993年第5期590-594,共5页Chinese Journal of Pathophysiology

摘　　要：18只失血性休克狗分为三组,Ⅰ组为对照组,Ⅱ组、Ⅲ组在循环失代偿期用声门外高频喷射通气(频率80次/min,驱动压0.2MPa,吸呼时比1:2)分别喷射空气和氧。结果:Ⅱ组血气、酸碱平衡和血浆丙二醛(MDA)含量的变化与Ⅰ组比无明显差异,而Ⅲ组PaO_2、PaCO_2、CO_2 CP和血浆MDA含量均显著高于Ⅰ组和Ⅱ组(P<0.01或P<0.05)。此结果提示,应用高频喷射通气喷射氧引起的高PaO_2可导致CO_2蓄积和脂质过氧化。18 dogs with hemorrhagic shock were divided into 3 groups. Group Ⅰwascontrol, group Ⅱ and Ⅲ were jetted with air or oxygen respectively and continuouslyoutside the glottis by HFJV (frequency 80 beat/min, driving pressure 0.2 MPa, I:E timeratio=1:2) during the uncompensated period. Results: Not much difference was foundbetween group Ⅰand Ⅱ in their blood gas, acid-base balance and plasma malondialdehyde(MDA). However, the P_aO_2, P_aCO_2, CO_2, combining power and plasma MDA in group Ⅲwere markedly higher than those of group Ⅰand group Ⅱ (P<0.01 or P<0.05) .Theseresults indingted that the high PaO_2, induced by jetting oxygen with HFJV outside theglottis might resulted in CO_2. retention and an increase in lipid peroxidation.

关 键 词：休克 出血性 高频喷射通气 丙二醛 

分 类 号：R605.971[医药卫生—急诊医学]