犬肠源性内毒素与失血性休克时的多器官结构损伤  

The relation of enterogenous endotoxin to the structural changes of various organs in hemorrhagic shock dogs

作　　者：郭炯[1] 王建中[1] 邱劲[1] 汤文良[1] 马琪[1] 王海燕[1] 彭秀花[1] 

机构地区：[1]新疆医学院病理生理教研室,乌鲁木齐830054

出　　处：《中国病理生理杂志》1993年第6期735-739,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金

摘　　要：本文对犬(n=10)不作预先处理而只将休克时间从2h延长至5h,结果不仅是肺,而且心、肝、肠、肾等均出现超微结构受损。主要表现为实质细胞肿胀,空泡样变性及细胞脱离,后者如肝细胞的联接解离和微绒毛消失;各类细胞的细胞器均有不同程度破坏,表现为线粒体肿胀,嵴溶解破裂,内质网扩张及脱颗粒现象;此外,还有心肌肌原纤维变细或溶解,肺和肠的毛细血管内皮细胞紧密联接裂开等。同时,血中肠源性内毒素含量随休克时间延长而递增,而且不同部位的血液其含量也不一样,以门静脉含量最高,动脉血次之,肝静脉血含量最低。提示诸器官损伤可能与肠源性内毒素有关。We only prolongated the course of shock from 2h to 5h, without predi- sposing the dogs. At 5h after hemorrhagic shock, the experimental results were asfollows: The ultrastructural damages were not only detected in the lung but also in theheart, liver, intestine and kidney etc. Major pathological lesions were: swelling of paren-chymal cells in various organs, vacular degeneration, and de-connection of cells. The laterwas shown as disintegration of hepatocyte-conjunction and disappearance of microvilli. Theorganelles of various cells ruptured to different degrees, for example, mitochondria swelledand its crista dissolved, endoplasmic reticulum dilated and de-granulated. In addition, thefibril of cardiac muscle thinned and dissolved, the capillary endothelial tight-conjunctionsof lung and intestine ruptured etc. The quantity of entero-endotoxin in plasma increasedin accordance with prolongation of shock, and its quantity was most abundant in portalvein, the next was artery and the last was hepatic vein. All experimental results showedthat the entero-endotoxin was related to the changes of ultrastructure of various organs.

关 键 词：休克 出血性 内毒素 

分 类 号：R605.971[医药卫生—急诊医学]