高碘对小白鼠甲状腺影响的观察研究  

EFFECT OF HIGH-IODINE ON THYROID OF MICE

作　　者：房维堂[1] 杨晓霞[1] 李平春[1] 姜瑞君[1] 胡丕英[1] 

机构地区：[1]山东省地方病防治研究所

出　　处：《中国地方病防治》1993年第5期263-264,266,共3页Chinese Journal of Control of Endemic Diseases

摘　　要：以高碘饲料喂养4组小白鼠,平均每只日摄碘量分别为:1组1μg,2组6μg,3组50.8μg,4组101μg.150天后发现甲状腺肿和甲状腺炎。动物每日摄碘量和甲状腺的重量、甲状腺滤泡直径呈正相关,和动物的体重、甲状腺滤泡上皮细胞的高度呈负相关。甲状腺的组织学改变属巨滤泡性胶样甲状腺肿。超微结构显示细胞功能处于静止减弱的形态。8只动物(占14%)甲状腺组织中有不同程度的灶性或弥漫性淋巴细胞浸润,和高碘人群中自身免疫性甲状腺疾病(AITD)的改变相似,为探讨高碘与甲状腺自身免疫病的关系,提供了有价值的实验资料。Four groups of mice were fed with high-iodine diet and the absorbed iodine of one mouse per day was 1μg( 1st group), 6μg(2nd group), 50. 8μg(3rd group), 101μg(4th group)respectively. Goiter and Thyroadenitis were observed after 150 days. Statistics showed that there were positive correlation between absorbed iodine per day and the weight,and follicle diameter of thyroid ,negative correlation to the animal weight and the height of epithelial cell of thyroid follicle. The histology change of thyroid belonged to large follicle colloid goiter. Ultramicroscope showed that the cell function was in a position of weakening state. There was different local or diffusa lymphocyte infiltration in goiter tissues of 8 mice(rate 14% ),which was similar to the change of AITD in people drinking high-iodine water. It proved valuable experimental materials in discussing the relationship of high-iodine to AITD.

关 键 词：碘 小白鼠 甲状腺肿 甲状腺炎 

分 类 号：R581.3[医药卫生—内分泌]