尿羟脯氨酸氨基多糖与大骨节病临床早期体征关系的研究  

Study on the relationship between hydroxyproline,glycosaminoglcan and the clinical early signs of Kashin-Beck Disease

作　　者：张矢远[1] 郭雄[1] 莫晓燕[1] 于志道[1] 

机构地区：[1]西安医科大学地方性骨病研究所

出　　处：《中国地方病学杂志》1993年第1期6-8,共3页Chinese Jouranl of Endemiology

摘　　要：本文对大骨节病临床早期体征指末弯、指关节增粗及手部 X 线异常改变,与尿液中羟脯氨酸、氨基多糖合量之间关系作了分析。结果表明,随着临床体征及 X 线干骺端、骨端异常改变的加剧,尿羟脯氨酸、氨基多糖含量相应降低,与正常组有十分显著差异(P<0.01),因此认为尿羟脯氨酸、氨基多糖要作为大骨节病早期诊断中颇有意义的生化指标。We explored the relationship between early flexion of distal joint of fingers,enlargement of finger joints and ab-normal X-ray changes in Kashin-Beck disease and the urinary excretion of hydroxyproline and glycosaminogly-can.The results showed that the amount of hydroxyproline and glycosaminoglycan in urine was significantly de-creased(p<0.01)as the clinical signs and abnormal X-ray changes in metaphysis become marked.Therefore theseresults suggested that hydroxyproline and glycosaminoglycan in urine could be the biochemical index for diagnosis ofKashin-Beck disease in the early stage.

关 键 词：大骨节病 羟脯氨酸 氨基多糖 

分 类 号：R684.102[医药卫生—骨科学]