广枣总黄酮对阿霉素引起大鼠心肌过氧化损伤的保护作用  

Protective effect of total flavonoids of Choerospondias axillaris on rat myocardiac peroxidation injury caused by adriamycin

作　　者：乌日娜[1] 张昕原[1] 张维兰[2] 王哲[2] 王玉莹[1] 李宝山[1] 

机构地区：[1]内蒙古民族大学西区中心实验室,内蒙古通辽028041 [2]内蒙古民族大学附属医院检验科,内蒙古通辽028041

出　　处：《中草药》2001年第6期527-529,共3页Chinese Traditional and Herbal Drugs

基　　金：内蒙古自然科学基金资助 ( NO.97130 31)

摘　　要：目的　通过广枣总黄酮 (TFCA)对阿霉素 (ADR)引起大鼠心肌过氧化损伤保护作用的研究 ,进一步证实广枣疗效可能与 TFCA抗氧化作用有关。方法　动物分为空白组、ADR组和实验组 (ADR+TFCA10 0 ,15 0 ,2 0 0mg/ kg组 )。以“心酶谱”、抗氧化酶做为检测指标。结果　 ADR组心酶谱、MDA均比空白组高 ,而抗氧化酶活性均比空白组低。TFCA干预后“心酶谱”、MDA下降 ,抗氧化酶活性上升。结论　 TFCA能抑制Object By studying the protective effect of total flavonoids of Choerospondias axillaris (Roxb ) Burtt et Hill (TFCA) on rat myocardiac injury caused by adriamycin (ADR) to provide further evidence showing the action of this medicinal herb is related to its antioxidation activities Methods Test animals were randomized into four groups: blank control, ADR control, and three experimental groups (ADR+TFCA 100, 150 and 200 mg/kg) The antioxidation enzyme activities were assessed by cardiac zymogram Results Cardiac zymogram showed that malondialdehyde (MAD) of the ADR control was higher while the antioxidation enzyme activities were lower than the blank control With the intervention of TFCA, cardiac zymogram showed lowering of MDA and elevation of antioxidation enzyme activities Conclusion TFCA can inhibit rat myocardiac peroxidation injury caused by ADR

关 键 词：广枣总黄酮 心酶谱 抗氧化酶 丙二醛 阿霉素 

分 类 号：R285.5[医药卫生—中药学]