2,4-二甲氧基苯甲醛的合成  

Syntheses of 2,4 - Dimethoxylbenzaldehyde

作　　者：韦立红[1] 崔凤侠[1] 郑建军[1] 杜小鹃[1] 尹志锋[1] 赵桂琴[1] 郭春燕[2] 

机构地区：[1]承德医学院化学教研室,067000 [2]张家口医学院化学教研室,075000

出　　处：《张家口医学院学报》2001年第4期26-27,共2页

摘　　要：目的:研究2,4-二甲氧基苯甲醛的合成。方法:以间苯二酚为原料,用Gatternann-Adams法合成2,4-二羟基苯甲醛,再经硫酸二甲酯甲基化。结果:总收率65.6％。结论:在2,4-二羟基苯甲醛的甲基化的反应中,我们改变了传统的以氢氧化钠为碱,以水为溶剂的方法,收率有较大提高。Objective: To modify the synthesis method of 2, 4 - Dimethoxylbenzaldehyde. Methods: 2, 4 - Dimethoxylbenzaldehyde was synthesized by methylation of 2, 4 - Dihydroxyl-benzaldehyde with dimethyl sulfate, derived from o - diphenol, by means of Gattemann -Adams. Results: The total yield was 65.6% . Conclusion: 2,4 - Dimethoxylbenzaldehyde Couldbe synthesized by methylation of 2, 4 - Dihydroxylbenzaldehyde with dimethyl sulfate instead of sodium hydroxide and distilled water. The tolal yield by this new method has been much improved compared with the old one.

关 键 词：苯甲醛 合成 二羟基 总收率 间苯二酚 溶剂 甲氧基 甲基化 改变 硫酸二甲酯 

分 类 号：R284.1[医药卫生—中药学] TQ46[医药卫生—中医学]