支气管肺泡生化成份在评价磷酸羟基哌喹疗效中的意义  

Siguificance of Biochemical Components of Brochoalveolar Lavage Fluid iu Evaluating Curing Effect of Hydroxyl Piperequine

作　　者：刘保连[1] 姚汝琳[1] 成一郎 杨青[1] 郭鼐 

机构地区：[1]山西医学院劳卫教研室,太原030001

出　　处：《中国公共卫生学报》1993年第4期235-237,共3页

摘　　要：用磷酸羟基哌喹预防性治疗大鼠矽肺,结果表明用药期间(除染尘后7天)支气管肺泡冲洗液(BALF)中总蛋白、总磷脂及磷脂谱低于石英组,停药后二棕榈酰卵磷脂(DPPC)升高,肺泡Ⅱ型细胞增生增殖,说明该药影响肺表面活性物质的代谢。BALF中生化指标的变化遵循一定的规律,把总蛋白、总磷脂,DPPC和脑磷脂(PE)结合起来作为评价药物疗效指标比常用的全肺胶原蛋白和病理学改变出现早。The changes of lipid, protein and phospholipid spectrum in (BALF)in the experimental rat silicosis treated preventively with HOPQ were studied. The results showed that hydroxyl piperequine could decrease the levels of protein,lipid and di- palmitoyal phospholipid of BALF induced by quartz. The changes of these biochemical indicators had rule to some ex- tent. These indicators could reflect the changes of pathologi- cal degree of silicosis. So it also illustrated the effects of HOPQ.

关 键 词：磷酸羟基哌喹 矽肺 

分 类 号：R598.2[医药卫生—内科学]