健康妇女尿吡啶并啉(PYD)的参考值测定与骨密度的比较  

Comparison of urine pyridinoline and bone mineral density in healthy women

作　　者：张丽雅[1] 任素梅[1] 李忆梅[1] 罗先正[1] 

机构地区：[1]北京友谊医院

出　　处：《中国骨质疏松杂志》1998年第1期13-16,共4页Chinese Journal of Osteoporosis

摘　　要：本文采用尿吡啶并啉（ＰＹＤ）测定法对２０６例健康女性的晨尿进行了检测，获得国人女性各年龄组ＰＹＤ的参考值，并与全国十三省市骨矿含量调查合作组测定的健康女性腰椎骨密度（ＢＭＤ）进行比较，结果表明女性尿ＰＹＤ在骨峰值时为一生的最低值，而在５０～５９岁ＢＭＤ下降最快时值最高。６０岁后，尿ＰＹＤ恢复到４０～４９岁水平且与年龄变化关系不明显，但骨密度却仍因骨重建速率不及骨吸收速率而随年龄增长而持续缓慢下降。女性尿ＰＹＤ、ＢＭＤ与雌激素关系密切，绝经初期雌激素水平骤然下降，此期ＰＹＤ升至一生最高值，而ＢＭＤ下降幅度为各下降年龄组之最。绝经晚期，由于机体对低雌激素水平相适应，尿ＰＹＤ回升，ＢＭＤ下降速率减慢。女性一生尿ＰＹＤ的变化规律，提示女性一生都应重视营养、体育锻炼及钙剂的补充，青春期尽可能使骨峰值提高，生育期应特别注意钙剂的补充，绝经后应适当补充雌激素，防止骨质疏松的发生。The morning uring of 206 healthy women was tested for pyridinoline (PYD),and the obtained reference values for different age groups were compared with the lumbar sping bone mineral density (BMD) values obtained from healthy women in 13 provinces by a collaborative investigation group.The results show that the urine pyridinoline value is lowest at the peak of BMD in the life of females,and highest when BMD declines most rapidly at the age from 50 to 59 years.But after 60 years of age,there is no relationship between age and urine pyridinoline level which falls to the same level as in 40-49 years of age.The bone mineral density,however,reduces slowly with age since the bone absorption rate is greater than that of bone reconstruction.PYD and BMD bear a close relationship to the estrogen.Urinary excretion of pyridinoline reaches peak at early stage of menopause,while BMD declines to the nadir.After menopause,the PYD level increases and the loss of BMD slows down.It is suggested that,for the purpose of preventing osteoporosis,women should pay attention to nutrition,exercise and supplementing calcium through life,elevate peak bone mass as far as possible at puberty,and supplement calcium agent during pregnancy and estrogen after menopause.

关 键 词：尿吡啶并啉 PYD 参考值测定 骨密度 

分 类 号：R681[医药卫生—骨科学] R446[医药卫生—外科学]