卵巢早衰患者骨代谢及其骨调节因素的水平  

Bone metabolism and level of boneregulating hormone in patients with premature ovarian failure

作　　者：姚吉龙[1,2,3] 杨晓薇[1,2,3] 秦惠琳[1,2,3] 王洪复[1,2,3] 郑怀美[1,2,3] 林金芳[1,2,3] 

机构地区：[1]深圳市宝安人民医院 [2]上海医科大学妇产科医院 [3]上海医科大学老年医学研究中心

出　　处：《中国骨质疏松杂志》1998年第3期26-28,共3页Chinese Journal of Osteoporosis

摘　　要：本文对２５例卵巢早衰患者进行了桡骨骨矿含量（ＢＭＣ）和骨代谢指标及其骨调节因素水平的测定，并以１０例正常妇女作对照。以了解该类患者之骨代谢及其骨调节因素水平与正常同龄妇女之间的差异。结果显示：卵巢早衰组ＢＭＣ的水平低于对照组和血清甲状旁腺素ＰＴＨ的值高于对照组，但均未见显著性差异。而空腹尿钙与肌酐（Ｃａ／Ｃｒ）、羟脯氨酸与肌酐（ＯＨＰｒ／Ｃｒ）比值和血清碱性磷酸酶（ＡＫＰ）的水平高于对照组、血清雌二醇（Ｅ２）和降钙素（ＣＴ）的水平低于对照组均有显著性意义（Ｐ＜０．０５或Ｐ＜０．０１）。提示：卵巢早衰患者骨代谢出现高转换失钙状态与其血清Ｅ２和ＣＴ水平的降低以及其骨骼对ＰＴＨ的敏感性增强有一定的关系。In order to further understand the bone metabolism and the level of bone regulating hormone in 25 cases of premature ovarian failure,a GMY1 instrument was used to measure the forearm mineral density(FMD),and fasting urinary calcium/creatinine ratio(Ca/Cr),hydroxyproline/creatinine ratio(OHPr/Cr),serum estradiol(E2),calcitonin(CT),parathyroid hormone(PTH)and alkaline phosphatase (AKP) were determined.The results showed that the FMD values and the serum PTH values in these patients were not different from those in control groups(P>0.5),but the values of serum CT and E2 in these patients were significantly lower than in control groups(P>0.01).The values of Ca/Cr ratio, OHPr/Cr ratio and seram AKP were significantly higher than in control groups (P<0.05,P<0.01,respectively).It is suggested that the bone metabolism in these patients is in a state of negative calcium balance;hence,there exists a tendency towards earlier occurrence of osteoporosis for these patients.

关 键 词：患者 卵巢早衰 骨代谢指标 对照组 调节因素 PTH 肌酐 CT 桡骨 正常妇女 

分 类 号：R711.75[医药卫生—妇产科学] R681[医药卫生—临床医学]