硒对慢性应激小鼠行为、海马神经元及脑LPO的影响  

Effect of Selenium on Behavior, Hippocampus Neuron and Brain Lipid Peroxide in Chronic Stress Mice

作　　者：胡旺平[1] 金延安[1] 李云[2] 舒思洁[3] 化长林[1] 

机构地区：[1]咸宁医学院生理学教研室,咸宁437100 [2]咸宁医学院病理学教研室,咸宁437100 [3]咸宁医学院临床药学系药理学教研室,咸宁437100

出　　处：《咸宁医学院学报》1998年第3期137-139,共3页Journal of Xianning Medical College

摘　　要：目的：探讨硒对应激损伤的作用。方法：建立束缚悬吊应激模型。采用旷场行为测定法、Nissl染色法和TBA比色法测定亚硒酸钠对慢性应激小鼠的行为、海马神经元和脑LPO的影响。结果：饮入亚硒酸钠的慢性应激小鼠脑LPO含量明显降低，海马神经元丢失减少，行为活动明显增多。结论：硒对应激引起的海马神经元损伤和抑郁样行为具有保护作用，该作用可能与其抗应激动物脑脂质过氧化有关。Objective To research the effect of selenium on stressful damage. Methods The mouse experimental model was established by restrainting and suspending. The effects of Na2SeO3 on the behavior, hippocampus neuron and brain lipid peroxide of chronic stress mice were observed and studied by open-field test, Nissl dye and TBA colorimetry. Results The content of lipid peroxide in brain decreased significantly, the loss of hippocampus neuron decreased, and behavior activity increased obviously after drinking the Na2SeO3 in chronic stress mice. Conclusion Selenium has a protective effect on hippcompus neuron damage and depressive behavior induced by chronicstress, this effect may be related to the selenium’s anti LPO function in brain.

关 键 词：硒 慢性应激 行为 海马神经元 脑LPO 

分 类 号：R338.1[医药卫生—人体生理学]