透明质酸钠预防术后硬膜外粘连的组织学和超微结构研究  

The Histologlcal and Ultrastructural Studies of Preventative Effects of Sodium Hyaluronate on Postoperative Peridural Fibrosis

作　　者：侯筱魁[1] 樊天佑[1] 

机构地区：[1]上海第二医科大学附属第九人民医院骨科

出　　处：《中华骨科杂志》1998年第5期301-303,共3页Chinese Journal of Orthopaedics

基　　金：卫生部科学研究基金

摘　　要：为了探讨透明质酸钠预防椎板切除后硬膜外粘连机理，本研究采用高分子量（１．５×１０６）透明质酸钠作实验植入材料，使用兔非相邻节段椎板切除动物模型进行实验研究。３０只兔共６０个节段随机分成两组，⑴２％透明质酸钠组；⑵生理盐水对照组。术后２、４、６、８周处死动物取材，分别做光镜、扫描电镜、透视电镜检查。结果表明：高分子透明质酸钠具有明显预防术后硬膜外粘连的效果。它具有屏障作用，能抑制成纤维细胞、炎性细胞的渗出。For the study of the mechanism of preventative effects of sodinm hyaluronate on peridural fibrosis after lumbar laminectomy, two- level noncontinual laminectomies were performed on rabbits models. 60 laminectomy levels of 30 rabbits were divided into two groups randomly: Group 1: 2% sodium hyaluronate; Group 2: Normal saline as control. The animals were sacrificed at 2,4,6,8 weeks postoperatively. The specimens were prepared for histological study and electron scanning microscopy. The result showed that 2% sodium hyaluronate significantly prevented the peridural fibrosis after lumbar laminectomy. It served as a barrier to prevent the migration of fibroblasts and inflammatory cells, inhibited the proliferation of fibroblasts and reduced the scar formation. It was suggested that 2% sodium hyaluronate is a good material to prevent postoperative peridural fibrosis.

关 键 词：透明质酸钠 硬膜外粘连 术后 预防 椎板切除 组织学 超微结构 高分子量 动物 取材 

分 类 号：R681[医药卫生—骨科学] R684[医药卫生—外科学]