慢性肝炎肝硬化中医证型与血清肝纤维化指标关系的探讨  

The Relationship on ths Syndrome’s Type of TCM and Serum Liver Fibrosis Symbol in the Patients with Chronic Hepatitis and Cirosis

作　　者：潘志恒[1] 高志良[2] 周元平[2] 陈琰碧[1] 

机构地区：[1]中山医科大学附属第三医院中医科,广州510630 [2]中山医科大学附属第三医院传染科,广州510630

出　　处：《现代消化病及内镜杂志》1998年第4期45-47,共3页

摘　　要：以放射免疫法测定152例慢性肝炎肝硬化患者的血清肝纤维化标志物透明质酸(HA)、Ⅲ型前胶原(hPCⅢ)和Ⅳ型胶原(Ⅳ-C)三项,旨在探讨中医证型与上述指标的关系。结果显示,各中医证型组的肝纤三项指标均为对照组升高,但改变有各自的特点,其中肝郁脾虚组的平均升高幅度最小,此为基础的两两比较发现,湿热中阻组肝纤三项均显著性升高;肝肾阴虚和瘀血阻络组以 HA、hPCⅢ升高为主。提示测定上述指标对慢性肝病患者的中医分型有一定指导意义,肝纤维化在肝郁脾虚阶段便已开始,湿热中阻是肝纤维化的活跃期,而血瘀则贯穿于肝纤维化的整个过程。To exploring the relationship on the Syndrome's Type of TCM and Serum Liver Fi- brosis Symbol(SLFS)in the Patients with Chronic Hepatitis and Cirosis.Hyaluronic acid(HA), human procollagen peptide Ⅲ(hPCⅢ), Ⅳ collagen(Ⅳ-C)in the sera of 152 patients with different syndrome type of TCM were measured by radioimmunossay.The results manifested that HA、 hPC Ⅲ and Ⅳ-C in all TCM type groups were higher than that in the normal group and every type group had it's own feature.The average rising range in the stagnation of liver-qi and deficiency of the spleen group(SLDS)were the smallest.Further analysis discovered that the SLFS in the stagnation of dampness and heat(SDH)group were statisticly raised.HA and PC-Ⅲ were statis- ticly raised in both the deficiency of the liver-yin and kidney-yin(DLK)and the blood stasis in the channels(BSC)group.It was indicated that the measurement of SLFS were valuable to the syndrome differentiation of TCM.Liver fibrosis began in the SLDS stage and became active in the SDH.Blood stasis existing through the whole process of the liver fibrosis.

关 键 词：慢性肝炎 肝硬化 中医 证型 血清 肝纤维化 肝郁脾虚 

分 类 号：R259.126[医药卫生—中西医结合] R259.752[医药卫生—中医内科学]