绝经后妇女尼尔雌醇治疗前后骨密度及骨代谢的变化  

Changes in bone mineral density and bone metabolism in postmenopausal women before and after treatment with nylestriol

作　　者：史敏[1] 巴雅[1] 杜红[1] 秦永德[1] 

机构地区：[1]新疆医科大学附属医院妇产科

出　　处：《中国骨质疏松杂志》1999年第1期46-48,共3页Chinese Journal of Osteoporosis

基　　金：新疆自治区教委科研基金

摘　　要：３０例绝经后妇女口服尼尔雌醇（ＣＥＥ３），每２周２ｍｇ共１年。治疗前后均采用单光子吸收法（ＳＰＡ）进行桡骨骨密度（ＢＭＤ）测量，进行血骨钙素（ＢＧＰ）、血降钙素（ＣＴ）、血雌二醇（Ｅ２）、血卵泡刺激素（ＦＳＨ）及空腹尿钙／尿肌酐（Ｃａ／Ｃｒ）测定。结果显示ＣＥＥ３治疗１年后治疗组骨ＢＭＤ增加１．１％，而对照组下降３．３％；血ＢＧＰ显著下降（Ｐ＜０．０１）；尿Ｃａ／Ｃｒ下降。本文提示，ＣＥＥ３能降低骨转换率。This study included the changes in bone mineral density and bone metabolism in 30 postmenopausal women before and after treatment with nylestriol (CEE 3)2mg every 2 weeks orally for one year.The BMD of radius was measured by using SPA machine,and serum BGP,CT,E 2,FSH and urine Ca/Cr were detected before and after treatment.The results indicated that after one year of treatment,the radial BMD increased by 1.1% in the treafed group and decreased by 3.3% in the control goup.Serum BGP significantly declined ( P <0 01) and urine Ca/Cr level decreased.It is suggested that nylestriol may be used to decrease bone turnover rate and prevent the postmenopausal osteoporosis.

关 键 词：绝经后妇女 治疗前后 骨密度 尼尔雌醇 骨代谢 BMD 桡骨 雌二醇(E2) 单光子吸收法 对照组 

分 类 号：R681[医药卫生—骨科学] R169.41[医药卫生—外科学]