血清骨钙素水平的观察  

Observation of level of bone gla protein in serum

作　　者：蔡桂英[1,2,3] 葛雪琳[1,2,3] 魏玲[1,2,3] 杨霞[1,2,3] 杨秀川[1,2,3] 王莉[1,2,3] 李金祥[1,2,3] 

机构地区：[1]华西医科大学生化教研室 [2]四川省人民医院内科 [3]华西医科大学附四院内科

出　　处：《中国骨质疏松杂志》1999年第2期29-32,共4页Chinese Journal of Osteoporosis

摘　　要：骨钙素（Ｏｓｔｅｏｃａｌｃｉｎ）又名骨谷氨酸蛋白（Ｂｏｎｅｇｌａｐｒｏｔｅｉｎ，ＢＧＰ），为骨组织的特异性蛋白，由成骨细胞生成，分泌入血。血清骨钙素（Ｓ－ＢＧＰ）是评估骨转换率及骨形成的特异性指标。本文为研究Ｓ－ＢＧＰ在正常及病理状态下的变化趋势，采用ＥＬＩＳＡ法观察了１２２例不同年龄段（０．５～８０岁，平均年龄为３４．１±１８．９，每隔１０岁为一年龄段）正常人，４６例原发性骨质疏松症及６６例代谢性骨病患者的Ｓ－ＢＧＰ水平。结果显示：（１）正常人Ｓ－ＢＧＰ水平为６．２±４．９ｎｇ／ｍｌ，其中男性为６．９±５．７ｎｇ／ｍｌ（ｎ＝６０），女性为５．８±４．３ｎｇ／ｍｌ（ｎ＝６２），Ｓ－ＢＧＰ与年龄呈明显负相关（ｒ＝－０．４５２，Ｐ＜０．００１）；（２）４６例原发性骨质疏松症患者（４２～８８岁，平均年龄为６１．３±１０．１岁）的Ｓ－ＢＧＰ水平，按不同年龄段统计，其值分别为１２．３±５．５ｎｇ／ｍｌ（４０～４９岁，ｎ＝５）、１０．９±６．４ｎｇ／ｍｌ（５０～５９岁，ｎ＝１７）及１０．７±６．９ｎｇ／ｍｌ（６０～８８岁，ｎ＝２４），各项数值分别与正常人相应年龄段Ｓ－ＢＧＰ水平相比都呈显著性差异（Ｐ＜０．００１）；（３?Bone gla protein (BGP,or osteocalcin) is a bone specific protein. BGP can be synthesized by osteoblasts and secreted into blood.Serum bone gla protein (S BGP) is a valuable marker for evaluating bone turnover and bone formation. In order to understand the change tendency of S BGP in normal and pathological condition, we systematically detected the levels of S BGP by using ELISA in 122 normal humans with different age stages (from 0.5 to 80 yrs,average age 34.1±18.9 yrs,10 yrs as an age stage),46 patients with primary osteoporosis (POP) and 66 patients with metabolic bone disease.The results are as follows.(1)The level of S BGP in normal humans was 6.2±4.9ng/ml,with 6 9±5 7ng/ml( n =60) in males and 5.8±4.3ng/ml( n =62) in females.The level of S BGP was negatively correlated with the age significantly (r=-0.452, P <0.001).(2)The levels of S BGP in patients with POP (from 42 to 88 yrs,average age 61.3±10.1 yrs) according to different age stage was 12.3±5 5ng/ml (40 49 yrs, n =5),10.9±6.4ng/ml (50 59 yrs, n =17) and 10.7±6.9ng/ml(60 80 yrs, n = 24),respectively. Every value compared respectively with S BGP in corresponding age stage of normal humans was significantly different ( P <0.001). (3)The levels of S BGP in 66 patients with metabolic bone disease (20 79 yrs,average age 46.9±15.1 yrs) were 6.6±2.6ng/ml( n =32)in chronic renal failure,8.1±3.3ng/ml( n =19) in hyperthyroidosis and,6.5±2.2ng/ml( n =16) in diabetes,respectively.These results respectively compared with the level of S BGP (4.4±1.7ng/ml) in corresponding age stage of normal humans (20 80 yrs,average age 40.4±15.8 yrs, n =96)were significantly different( P <0.001).The results of this study provide important parameters for clinical and basic research in bone metabolism.

关 键 词：正常人 BGP 平均年龄 血清骨钙素 患者 不同年龄段 观察 代谢性骨病 骨转换 特异性蛋白 

分 类 号：R681[医药卫生—骨科学] R581.1[医药卫生—外科学]